LA BioMed Launches MDMA-Assisted Therapy Study for Social Anxiety in Autistic Adults


Researchers at the Los Angeles Biomedical Research Institute announced plans to initiate a novel study into the safety and effectiveness of MDMA-assisted therapy. 

This study is the latest in an expanding program of research into the therapeutic use of MDMA by the nonprofit Multidisciplinary Association for Psychedelic Studies (MAPS). 

The press release reads:

LOS ANGELES, CALIF. — Seeking new therapies for the treatment of social anxiety in autistic adults, researchers at the Los Angeles Biomedical Research Institute (LA BioMed) announced today that they are initiating a novel study into the safety and effectiveness of MDMA-assisted therapy.

The study is the latest in an expanding program of research into the therapeutic use of MDMA by the nonprofit Multidisciplinary Association for Psychedelic Studies (MAPS). The research seeks to examine effective treatments for adults on the autism spectrum, who often face social adaptability challenges and greater anxiety, depression, and victimization than typically developing adults.

Conventional prescription medication that may help other adults is often ineffective in autistic adults. Moreover, difficulties in establishing a rapport with a therapist can interfere with conventional psychotherapy.

“We know we need new supportive treatments, and we have anecdotal evidence that autistic adults who had experimented with MDMA experienced a reduction in anxiety and an increased confidence in their abilities to interact socially,” said Charles Grob, MD, LA BioMed’s lead researcher for the study. “We also have been impressed with the results of other MAPS-sponsored MDMA-assisted psychotherapy research, which has demonstrated clinical improvement in patients with chronic posttraumatic stress disorder (PTSD). With our current study, we will administer MDMA in a carefully controlled environment to establish the safety and efficacy of MDMA-assisted therapy in a small sample of autistic adults with social anxiety.”

MDMA (3,4-methylenedioxymethamphetamine) is a synthetic compound first developed by the Merck pharmaceutical company in 1912. Therapists began to explore MDMA’s use in therapeutic settings in the 1970s, including to reduce moderate depression and anxiety among their adult patients.

Legal therapeutic use came to a halt in 1985 when MDMA was criminalized as a result of widespread recreational use. Illegally manufactured “Ecstasy” or “Molly” is usually adulterated and often contains no MDMA.
Alicia Danforth, PhD, an LA BioMed researcher for the study, has previously conducted interviews with numerous adults on the autism spectrum who have taken MDMA recreationally and reported a reduction in social anxiety. She reported that 72% of the more than 100 autistic adults she surveyed reported feeling “more comfort in social settings” as a result of using MDMA recreationally and 77% found it “easier than usual to talk with others.” In some cases, she said, these effects lasted a year or more. But she pointed out that the recreational drugs identified as MDMA, or “Ecstasy,” may not necessarily contain MDMA.

“This new study will give us a chance to determine the actual effects of differing dosages of medication that we know for certain is pure MDMA on adults on the autism spectrum,” she said. “If the results of this research warrant further investigation, data from this study will be used to design additional clinical trials.”

Read more at MAPS.org

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