DMT is simultaneously the most potent and short-lived of psychedelic experiences. Just ten minutes can feel like an eternity in the immersive alternate universe that DMT catapults users into — but what if it could last hours?
Neurobiologist Andrew Gallimore and DMT research pioneer Rick Strassman have developed a technology that can do just that via continuous administration of DMT via intravenous injection.
As they explain in the introduction to their study, DMT’s produces extraordinary changes in human consciousness:
N,N-dimethyltryptamine (DMT) produces some of the most extraordinary changes in consciousness of any naturally-occurring psychedelic substance. Users consistently report the complete replacement of awareness of the normal waking world with a bizarre and complex “alternate universe” filled with a variety of visual objects, including what appear to be sentient, intelligent, and powerful “beings,” many of which actively interact with the individual (Strassman, 2001, 2008; Luke, 2011; Gallimore, 2013). Furthermore, the endogenous production of DMT in humans is well-established (Barker et al., 2012), although the biological significance of this remains to be elucidated. DMT is actively transported across the blood brain barrier in rats and dogs (Sangiah et al., 1979; Takahashi et al., 1985; Yanai et al., 1986), and a similar mechanism plausibly exists in humans. DMT is also a substrate for the human serotonin and monoamine vesicular transporters (Cozzi et al., 2009). The key enzyme for its production, indolethylamine N-methyltransferase, has been detected in the brain, pineal gland, and retina of primates (Cozzi et al., 2011). Taken together, these data suggest that DMT may have a significant role in human neurophysiology, consciousness, and the visual system.
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