DMT is a core tryptamine. It is naturally occurring, and one of the most powerful and life-changing psychedelic substances in the world, making it one of the most popular psychedelics next to LSD and magic mushrooms.
Table of Contents
What is DMT?
DMT is a naturally occurring tryptamine. The DMT molecule structure is found within almost all of the substances of its tryptamine class. The DMT tryptamine class counts at least 400 species of plants and fungi. Because of their molecular structure, all psychoactive hallucinogenic tryptamines are similar to each other with DMT and psilocybin being most popular.
- God molecule
- Jim jam
- Jungle spice
N,N-Dimethyltryptamine—or DMT for short—is a tryptamine class alkaloid molecule. We can separate two main ways of production of DMT: Extraction and Synthesis. Extraction methods vary greatly, but the most common way of extraction from plant material is with MHRB (mimosa hostilis root bark) and ACRB (acacia confusa root bark).
Forms & Ways of Consumption
It is a common misconception that DMT is consumed successfully by smoking. Direct open flame will cause it to burn and become inactive.
Instead, DMT becomes active when vaporized at a temperature around 160 degrees celsius (320°F). Users can also choose to snort it, which is much easier in its salt form (such as fumarate, citrate, or acetate for better absorption through mucous membranes).
This is also true of cocaine, which is sold on the street in its cocaine HCL form. Some people choose to basify cocaine with baking soda (or a similar basic ingredient) and then vaporize it. This is freebase or “crack” cocaine. Unlike cocaine, DMT is almost always in its freebase form.
Other Ways of Consuming DMT
Another way of consuming DMT is orally in combination with MAOI (monoamine oxidase inhibitors). Users can achieve this in many different ways, such as cooking the plants that contain these compounds together for hours, or by extracting the compounds and then consuming them in pill (nicknamed in some psychedelic communities as pillahuasca) or “parachute” form, which is where one places the substance inside a piece of thin paper and then swallows it.
Many indigenous people groups from the Amazon region consume a combination of DMT and MAOI by combining two plants, most often Banisteriopsis caapi (also called ‘ayahuasca vine” or just “caapi”), and psychotria viridis or alba (also known as “chacruna”) in a huge pot, where they then cook them while praying.
Ayahuasca and DMT Alternatives
Cultivators have also developed so-called psychotria nexus more adapted to live in colder climates. Alternatively, plants like Acacia confusa or Mimosa hostilis (Jurema) may be used to provide the DMT, witheganum harmala (Syrian rue) for the MAOI.
DMT comes in many shapes and sizes, and it is usually pale yellow-orange to pure white crystals when extracted. Oxidation, oils, and other tryptamines such as NMT can cause yellowing. A dangerous contamination of NaOH mixed with small particles of plant matter can also cause yellowing, and usually causes DMT to be brownish more than yellow. This can cause lung problems if taken by vapor, or stomach problems if consumed orally.
Are there any differences between original and alternative forms of DMT and Ayahuasca?
The difference will be in the taste and potency. There are some anecdotal reports that suggest that if DMT is a bit oily, it is actually stronger since it can also contain other alkaloids.
The community often refers to some of these “stronger forms” of DMT as Jimjam and Jungle spice. Jungle spice contains small amounts of DMT, but higher amounts of other alkaloids from mimosa hostilis.
Although pure DMT was not synthesized until 1931, ancient use of ayahuasca – which includes a main component of dimethyltryptamine – has been traced back thousands of years.
Traces of N,N-dimethyltryptamine can be found in some ancient artifacts due to many plants containing the compound naturally. When ingested with another plant (typically a MAOI), it produces a psychedelic experience. Another tobacco plant containing a MAOI was used by indigenous peoples use to enhance the ayahuasca trip. This is a special kind of tobacco scientists call Nicotiana rustica, which is not to be confused with the ordinary Nicotiana tabacum found in commercially available cigarette products.
History of Yopo
Yopo was first reported in 1801 by the explorer A. Von Humboldt among the Maypure Indians of Orinoco. It is one of many visionary snuffs that several tribes in South America have used for over 4,000 years.
Making Yopo requires dried seeds of the Anadenanthera Peregrina tree. The scientific name Anadenanthera Peregrina makes reference to the Sanskrit word “ananda” which means “bliss.”
Did Masons Use DMT and Ayahuasca?
We can find references to Acacia plants (containing DMT) in many excerpts of Masonic literature, as it was fairly popular in Masonic circles up until the 1700s. In an allegory presented to all candidates of Freemasonry, Alessandro Cagliostro serves an ayahuasca-like brew containing Acacia to initiates in order to “raise” the candidates’ “spirits” before his lecture.
Ayahuasca (an orally active form of DMT) is a brew used by multiple ancient people and tribes for shamanic purposes, and is believed to help humans better communicate with each other, their emotions, deities, ancestors, and the spiritual world overall. Ayahuasca brew contains two main components, DMT (the psychedelic component) and an MAO inhibitor. The MAO inhibitor stops the metabolism of DMT in the human body, thus allowing for its psychedelic effects to occur.
The Scientific Breakthrough on DMT
In 1931, British Chemist Richard Helmuth Fredrick Manske became the first to synthesize DMT. However, it wasn’t until 1955 that DMT was identified as an ingredient in A. peregrina seeds (used to make Yopo and cohoba snuffs). This marked the first time DMT was documented as naturally occurring in a plant or animal. After this finding, speculation began to rise that it possessed psychoactive effects. The following year in 1956, a scientific publication by Stephen Szara was released, confirming that it was indeed psychoactive.
Scientific studies (ranging from 1961 to 2015) have since discovered that mammalian lungs and brains synthesize DMT, as can human blood, urine, and cerebrospinal fluid.
In December of 2000, Dr. Rick Strassman published DMT: The Spirit Molecule, where he summarized his academic work, experimental studies, and his own conclusions about the endogenous properties of DMT. After twenty years of pause from psychedelic research, Strassman was the first person in the US to undertake human research with psychedelic substances.
Laws and Legal Status
Are DMT and Ayahuasca Legal in South America?
DMT is classified as a Schedule I drug under the United Nations 1971 Convention on Psychotropic Substances. However, this action did not regulate natural substances containing DMT, such as ayahuasca. In December of 2004, the United States Supreme Court lifted a stay allowing the Brazil-based União de Vegetal (UDV) church to use a tea containing DMT for their Christmas services that year.
Gonzales v. O Centro
Two years later, in Gonzales v. O Centro Espirita Beneficente Uniao do Vegetal, the court ruled that the federal government must allow the UDV to import and consume the tea for religious purposes under the 1993 Religious Freedom Restoration Act. After ruling in favor of the three Santo Daime churches, Judge Owen M. Panner issued a permanent injunction barring the government from penalizing or prohibiting the sacramental use of “Daime tea,” which contains ayahuasca.
Are DMT and Ayahuasca Legal in South America?
Law prohibits DMT in most countries. There are some exceptions for the DMT-containing ayahuasca, often for religious and spiritual purposes. However, possession and use of ayahuasca is legal in Brazil, which is why so many ayahuasca retreats exist in Brazil. Similarly, many know Peru for ayahuasca use, as it is legal to use and possess. Locations in Peru also offers Ayahuasca retreats.
Are DMT and Ayahuasca Legal in Europe?
Although there are no laws prohibiting ayahuasca in Italy, there have been recent arrests of individuals using ayahuasca in the Santo Daime Church. Similarly to Italy, there is no specific law prohibiting ayahuasca in Spain. Despite this, arrests happen to members of the Santo Daime church for its use.
Is DMT Legal in Netherlands or Amsterdam?
From October 1st, 2019, Ayahuasca is illegal in the Netherlands . This ruling came to power after a woman tried importing 33 kilos worth of ayahuasca brew across the border. After the decision of the lower court that she is guilty, she took the issue to the Supreme Court. Supreme Court on the account that this would repress the religious freedoms. The Supreme Court, however, ruled that this was an infringement on the public health- making this an illegal act. It is still highly unlikely that you will be prosecuted for possession.
Is DMT Legal in Australia?
Currently, there are no specific laws that address ayahuasca in Australia. While there have been no prosecutions for ayahuasca, Australia has other harsh laws for other drugs, including DMT.
Before we can discuss whether or not ayahuasca is toxic, we first need to define what makes a substance toxic. Toxicity is defined based on the levels of exposure required for a substance to cause harm to a human or animal. The level of toxicity is measured based on the dose required to cause harm to a human. Even water can be toxic in too high of a dose and lethal snake venom can be non-toxic in a small enough dose. LD50 is a common measurement of toxicity, which measures the lethal dose for half of the tested organisms.
Scientists consider this chemical toxic since it technically damages some cells and tissues after ingestion. But multiple studies have shown no connection between DMT and any kind of toxicity, even at high doses.
There is some research that shows the neuro-regenerative and antidepressant effects of ayahuasca, along with some studies that indicate other DMT analogues (such as 5-meo-DIPT) may in fact be neurotoxic.
Experiential knowledge suggests that users of DMT not mix it with other substances besides MAOI. It is recommended that users follow an MAOI diet before consuming an MAOI.
Using any phenethylamines such as mescaline, 2CB or MDMA in combination with MAOI’s, can be extremely dangerous. Possibly causing adverse effects and even death for users with serotonin syndrome. People who have a history of epilepsy or schizophrenic disorders should always check with their psychiatrists before taking any substances.
Pure DMT has not shown evidence of being dangerous to healthy users, but much research needs to be done. The effects of DMT can cause people to stumble, fall over, and hurt themselves badly. Extremely challenging trips can leave a person with PTSD.
There is almost no evidence published about overdosing and DMT.
When taken by vaping, DMT typically lasts anywhere from 5 to 30 minutes. Effects of vapourized DMT can be prolonged by mixing it in a smoking blend called changa, which typically contains plants that have MAOI or to which an MAOI has been added.
DMT is a 5-HT2a agonist, meaning that it binds to some of yours serotonin receptors. Unlike other hallucinogens, DMT will cause extremely strong visual hallucinations such as OEV (open eye visuals) and CEV (closed eyes hallucinations). “Machine elves”, as Terence McKenna would put it, sometimes occur as a common visual experience.
Common Side Effects
Users report that DMT tolerance build-up is extremely low. In most cases, taking DMT one hour after the first vaporized intake will create effects on the same level as the first time. Ayahuasca tolerance is similar, but it can take up to a day for the tolerance to subside — possibly because of the MAOI content. Additionally, DMT does not cause cross tolerance, as is the case with LSD or Psilocybin from magic mushrooms, where the tolerance may be noticeable for up to a week.
As with other psychedelics, DMT is related to a condition known as hallucinogen persisting perception disorder (HPPD), which affects around 1% of all users of psychedelics. HPPD can manifest itself through visual snow similar to the static pattern seen on analog TVs when there is no signal coming through. However, this is not a major concern to the members of the community since it usually ceases over time. With that said, cannabis does seem to prolong this disorder.
How Long Does DMT Stay in Your Body?
DMT stays in your system for a short amount of time due to enzyme monoamine oxidase, which destroys it quickly after ingestion/inhalation. However, consumption of the MAOI can increase the duration of effects and longevity of this molecule.
How do you extract DMT from frogs?
Extraction of DMT does not come from frogs. However the similar substances 5-MEO-DMT and 5-HO-DMT come from the skin of Incilius alvarius. The more common name for this species is the Colorado River Toad. 5-MEO and 5-HO are NOT good substitutions for DMT, as they are more potent and orally active. There is only one species of frogs that causes hallucinations, the Phyllomedusa bicolor. Evidence has also shown that extracting 5-MEO-DMT and 5-HO-DMT from frogs is harmful to ecological health the species.
Do all frogs make DMT?
No, frogs do not make DMT. Toads do. Not all toads produce it.
Synthetic or toad?
Essentially no difference exists between naturally occurring (extracted) and synthetic DMT. They can both be dangerous if not prepared and extracted properly.
Does DMT go bad?
It can oxidize over time and become less potent, but there are conflicting claims about this in the community.
This DMT and Ayahuasca guide is for educational purposes only. While it is our belief that choosing to consume psychedelics is an inalienable human right, many psychedelic substances are currently illegal in the United States.
Our substance guides provide the public with the most accurate and reliable information about psychedelic substances that currently exist. We have compiled research, scientific studies as well as experiences and thoughts from the psychedelic community. We do not include all the scientific research and studies. Rather, we curate each our guides to reflect the most relevant insight backed by the most credible evidence. That being said, we are just at the beginning of studying these substances.Everyday we are learning something new. Knowledge is power! Have a bite. If you have relevant information or updates concerning the research and studies of psychedelic substances, please reach out to [email protected]. We appreciate your contribution. –RS