Mescaline Guide: Effects, Common Uses, Safety

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Mescaline has a deep seated history in Native American cultures, playing a large role in many of their ceremonies related to spiritual healing. It was also one of the first psychedelics to enter Western culture, paving the way for LSD and Psilocybin. Despite this, it hasn’t gained the same popularity in modern times. In a recent global survey of drug use, Mescaline only appeared on Mexico’s list of the top 20 drugs used. Furthermore, out of the top 20 most used drugs in Mexico, Mescaline use rated at 4.4%.

Best known as the primary active compound in the San Pedro, Peyote, and Peruvian and Bolivian Torch cacti, these plants were commonly used in shamanic rituals throughout the Americas. Shamans would make a ceremonious tea by grinding up the cactus until it became a slushy liquid. After placing the ground up cactus into a ceremonial bowl, the shaman passed it around in liquid form for people to drink, oftentimes right before evening. Performing this ceremony healed a person’s spirit through an intense introspective trip.

Table of Contents

  1. Overview
  2. History
  3. Synthesizing Mescaline
  4. Pharmacology
  5. FAQ

Overview

Pure Mescaline dates all the way back to 1897 when a German chemist, Arthur Heffter, first isolated and identified it as the active compound in Peyote. Shortly after, in 1919, Ernst Späth first synthesized Mescaline in a laboratory setting. Mescaline is thus the first psychedelic compound to be synthesized. Since then, many discovered a variety of ways of synthesizing Mescaline, using different starting materials and techniques.

Mescaline produces similar psychedelic effects to LSD and psilocybin. The full trip on a “common” dose typically lasts around four to eight  hours, so pretty similar to the length of a psilocybin trip. The visual effects of Mescaline, while similar to LSD, have their own unique appearance. Many people describe the visuals as a “geometrization” of regular objects, similar to a Picasso painting and  other great cubist artists.

What is Mescaline 

Mescaline is a plant-based phenethylamine psychedelic substance. It is naturally found in cacti from the Lophophora and Echinopsis (formerly known as Trichocereus) genera. The most common of these cacti are the Peyote, San Pedro, and Peruvian Torch. They are slow-growing cacti found in the southern United States, Mexico, Central America, and South America. A typical preparation of these cacti includes cutting off the top of the cacti while leaving the taproot for new heads to grow. The tops of the cacti are then dried and either chewed or steeped into a tea in order to produce Mescaline’s psychedelic effects.

Some acacia species contain Mescaline as well, such as Acacia Berlandieri and Fernasiana. Typically, Acacia species are leafy trees with psychoactive alkaloids commonly found in their barks and leaves. Unlike the cacti mentioned earlier, acacia species that contain Mescaline also tend to have much higher concentrations of other psychoactive compounds. This gives the Acacia species a unique trip due to the combination of various psychoactive compounds.

Regardless of its source, Mescaline produces hallucinogenic and self-exploratory effects with a unique empathic element when consumed. This unique energy, along with the psychedelic effects, gives Mescaline its particular quality as a spiritual healing plant. This energy comes from Mescaline’s chemical composition, which is similar to MDMA, 2CB and Amphetamines. MDMA is an “empathogenic” substance that is proving to be successful in treating addiction and PTSD. Thus, Mescaline might share some of these same properties due to its similarities. We’ll get further into this in the next section!

Scientific Name

Mescaline molecule

Mescaline is the common name for 3,4,5-trimethoxyphenethylamine. It is a Phenethylamine type molecule that puts it in the same category as substances such as MDMA, MDA, 2CB and various Amphetamines. This similarity with Amphetamines gives Mescaline an empathetic aspect to it not seen in most other psychedelics. Like MDMA, Mescaline increases both cognitive and emotional empathy in its users.

Emotional empathy is when you unconsciously feel the emotions of someone else, while cognitive empathy is when you actively try to understand how and why someone is feeling the way they do. While it is still very introspective like most psychedelics, it projects the user outward as well, by enhancing their ability to empathize with others and reflect on how their actions affect the world around them.

There are other, less known, Phenethylamine psychedelics such as 25I-NBOMe, 2C-B, DOB, and many others. These compounds tend to have that same energetic feel as Mescaline, but most other Phenethylamine psychedelics don’t result in as deep of a trip. They tend to be closer to MDMA with limited visuals.

Forms & Ways of Consumption

Mescaline, when it is pure, comes in a white crystalline or powdered form. Some imperfections may appear due to oils or plant materials left behind during the extraction process. Another, more complicated method of extraction can yield more concentrated and pure substances such as Mescaline sulfate or Mescaline hydrochloride (HCL). One can take Mescaline Sulfate and Mescaline HCL orally, nasally or rectally. Needles however are a dangerous form of consumption, and should not be used to take any substance. 

There are two ways of making Mescaline, either extracting it directly from a Mescaline-containing plant or synthesizing it in a lab. Synthesizing Mescaline in a lab produces a purer product, but it is almost never done, unless it’s for a scientific study. Usually, Mescaline is made by extracting it from a plant such as Peyote. This is a less expensive way of making Mescaline thus it’s more common. When Mescaline is extracted from a plant, sometimes there will be some residual plant matter left behind, resulting in a slightly tanned product.

Dosage

The suggested dosage by Erowid, a renowned resource for drug safety, is as follows:

0

These dosages are based on pure Mescaline. They will vary depending on the process used to create Mescaline, as they will have different molecular weights. Molecular weight refers to the mass of a specific molecule. Processes that create variations of Mescaline with a higher molecular weight, such as Mescaline Hydrosulfate, will require a higher dosage than the doses recommended in the table above. Variations with a lower molecular weight, such as Mescaline Hydrochloride, require a smaller dosage than the recommends table above. A more detailed guide on how to calculate dosage based on the extraction or synthesis process can be found on the Erowid site.

Conduct a test dosage for any substance that you use, well below the threshold dose. This helps to determine any possible allergies or bad reactions to the substance. It takes a relatively high dose to feel the effects of Mescaline thus it cannot come in the form of a microdot or tab like LSD can. The amount required to feel the effects of Mescaline makes it impossible to produce in the form of microdots or tabs. Thus, if you get microdots or tabs, know that it is not Mescaline. Since pure Mescaline comes in a white crystalline or powdered form, it will look the same as a whole slew of other substances. This makes testing Mescaline far more important than others that have a unique appearance, such as liberty cap mushrooms. Regardless, you should always test your substances!

History

Mescaline is a natural psychedelic found in several cactus species such as Peyote and San Pedro. Native American cultures would use these cacti as a tool in spiritual healing and shamanic rituals. The San Pedro cactus was so important to the Andean Shamans, they referred to it as the primordial soup of the cosmos. Tribes in Texas and New Mexico, such as the Chichimeca and Tarahumara, would even use Peyote to ease the pains associated with long-distance migrations by foot.

Isolating Mescaline

Arthur Heffter was the first person to isolate Mescaline in 1897. He isolated it from the Peyote cactus, which was already known to produce hallucinogenic effects. Heffter even went as far as testing the substances he isolated from the Peyote cactus on himself. Thus, he became the first “psychonaut.” Ernst Jünger gave him that name in a journal that he used to document his personal experimentations with drugs. Jünger was a decorated German soldier in World War I and the son of a successful chemist. This likely fueled his enthusiasm to experiment with different psychedelics to cope with PTSD. Furthermore, Mescaline was the first psychedelic compound to be isolated, nearly 50 years before Hoffman synthesized LSD. These two substances, Mescaline and LSD, were the first to be classified as psychedelics. 

Hefftner was the first person to isolate Mescaline from the Peyote cactus. He was not however the first to synthesize it in a laboratory setting. Ernest Spat, an Austrian chemist, first synthesized Mescaline in 1919. Thus, Mescaline was also the first psychedelic compound to be synthesized in a laboratory setting. He created Mescaline out of 3,4,5-trimethoxybenzoyl chloride.

Synthesizing Mescaline

After Spat synthesized Mescaline, other chemists figured out many other ways to synthesize the substance as well. The most notable of these syntheses is Albert Hoffman’s rearrangement of 3,4,5-trimethoxyphenylpropionamide to create Mescaline. This rearrangement created an entirely new way of synthesizing chemicals in laboratory settings, now known as the Hoffman Rearrangement. Hoffman’s method is still used by organic chemists today.

Alexander Shulgin, one of the most popular psychedelic scientists to this day, named Mescaline as his inspiration to pursue research into psychedelic and mind-altering substances. Just like Heffter and Hoffman, Shulgin was also a proponent of testing these substances on himself. He would go on to popularize MDMA in psychedelic therapy settings, and most notably create the Shulgin Rating Scale. The Shulgin Rating Scale is still in use today as a way of describing the effects of psychoactive compounds. It includes specific vocabulary that refers to the visual, auditory, and physical abnormalities caused by various substances.

Aldous Huxley: Doors to Perception

Mescaline’s inspirational effects didn’t stop there. In 1954, Aldous Huxley wrote an entire book, Doors of Perception, detailing a Mescaline trip he had in 1953. After releasing Doors of Perception, he met strong criticism from practitioners of the Christian faith. The most prominent amongst his critics was Robert Charles Zaehner, an Oxford University Professor. He said that neither Mescaline, nor any mind-altering substance, was valid in the eyes of the Christian God. Famously, Huxley then questioned why the Christian faith accepted alcohol, but considered other forms of coping and altering one’s state of mind to be pervasive. This is still a point of contention in the psychedelic community today. Most societies and religions reject mind-altering substances but accept alcohol use, which is more detrimental to one’s health.

One potential side effect of Mescaline and most other psychedelics is HPPD (Hallucinogen persisting perception disorder). In a famous story, Jean-Paul Sartre, a french existential philosopher, participated in an experiment at a hospital in Paris. After being injected with Mescaline, he had persisting visual distortions for weeks. 

Sartre however experienced more severe effects from HPPD. He reported that crabs were following him everywhere he went for an entire year. Eventually, he grew concerned that he would not be able to differentiate between his hallucinations and reality, so he got help from a psychoanalyst. He was able to recover his faculties relatively well. Nevertheless, crabs became a recurring theme in his work after that trip.

Laws and Legal Status

The United States made Mescaline an illegal substance in the Comprehensive Drug Abuse Prevention and Control Act in 1970. It was classified as a Schedule 1 hallucinogen. According to the DEA, a drug is classified as a Schedule 1 substance under these conditions: it must have no currently accepted medical use, a lack of safety standards under medical supervision, and at least some potential for abuse. 

The United Kingdom considers Mescaline a Class A drug, which makes it an illegal substance without medicinal value. It is however legal to purchase and carry dried cacti containing Mescaline.

Mescaline became an internationally prohibited substance according to the 1971 Convention on Psychotropic Substances. Since then, other countries have chosen to create their own regulations for Mescaline. Australia treats Mescaline as a Schedule 9 substance under the Poisons Standard of 2015, making it an illegal substance. A Schedule 9 substance is considered to have a high potential for causing harm at low doses, and to be dangerous to handle. In Canada, France, The Netherlands, and Germany, pure mescaline and dried mescaline cacti are illegal. However, anyone may grow the Peyote, San Pedro, and Peruvian Torch cacti, but intent to use is illegal. 

Pharmacology 

Mechanism of Action 

When Mescaline enters the body, it binds to the 5-HT2A and 5-HT2C serotonin receptors in the brain due to its structural similarities to the neurotransmitters dopamine and noradrenaline. The 5-HT2A and 5-HT2C receptors are mostly located in the neocortex of the central nervous system. These play a role in how we perceive the world through our senses. Scientists believe Mescaline binding to these receptors causes the psychedelic and hallucinogenic effects.

Toxicity

Before we can discuss whether or not Mescaline is toxic, we first need to define what makes a substance toxic. Toxicity is defined based on the levels of exposure required for a substance to cause harm to a human or animal. The level of toxicity is measured based on the dose required to cause harm to a human. Even water can be toxic in too high of a dose and lethal snake venom can be non-toxic in a small enough dose. LD50 is a common measurement of toxicity, which measures the lethal dose for half of the tested organisms.

No clear data on the toxicity of Mescaline exists. However, lab trials did determine oral doses in rats, in order to establish an LD50. LD50 refers to the lethal dose for half of the tested organisms. The trial found the LD50 to be 880mg/KG. For an average adult, this would be around 60 grams of pure Mescaline. A direct translation between LD50 in rats and humans however is not possible since their metabolisms differ. Thus far, there hasn’t been any recorded death from a Mescaline overdose. 

Little historical data exists on the effects of prolonged use of Mescaline. So, it is best to stay safe and keep your number of trips to a minimum. 

Interactions

Mescaline causes cross-tolerance with other serotonergic psychedelics such as LSD and psilocybin. Thus, if you use substances like Mescaline, LSD, or psilocybin within a few days of each other, all of these substances will have a lesser effect. 

TripSit Guide to Drub Combinations Chart

Many people who use psychedelic substances frequently during a short span of time report losing the magic in later uses. This is when someone is not able to receive many of the benefits that come along with using psychedelics. Trips will cease to have the same positive after-effects, such as an elevated sense of connectedness, overcoming bad habits, and much more.

Common Side Effects

As with other psychedelic substances, common side-effects include:

  • Vasoconstriction
  • Dilated pupils
  • Temporary bladder issues
  • Constipation
  • Headaches
  • Nausea
  • Sweating
  • Difficulties speaking
  • Difficulties having sexual intercourse

Due to the introspective nature of Psychedelics, it is easy for users to spiral out of control if they have existing issues with anxiety and fear. Therefore, make sure you’re in a right state of mind, or at least check-in with where you’re at mentally and emotionally before you use any psychedelic substance. And, perhaps it goes without saying but no one should drive or use heavy machinery while on Mescaline or any mind-altering substance.

Adverse Effects

As with most psychedelics, one can build up a tolerance to Mescaline fairly quickly, and it could be noticeable even after your first use. If used repeatedly over a short span of time, it will require higher doses to experience the same effects. As mentioned earlier, one can build up a “cross tolerance” to LSD, Psilocybin, and all other serotonergic substances. To avoid developing a cross tolerance to Mescaline, or any psychedelic, one needs to be aware of how frequently they’re using substances that react with their serotonin receptors. Most psychedelics do react with your serotonin receptors. Thus, make sure to space out any psychedelic use to experience their full effects.

As with every other psychedelic, mescaline can cause HPPD (Hallucinogen persisting perception disorder). This disorder usually manifests as “visual snow,” which is when you see visual particles in the air blurring your sight. In extreme cases, HPPD can result in full blown hallucinations for prolonged periods of time.

There is a certain chance that psychedelics such as Mescaline can cause PTSD (Post traumatic stress disorder) during challenging trips. This is why you should always have an experienced tripsitter who can guide and calm you if you begin to have an intense experience. You should also make sure to consciously evaluate your current mental state prior to taking any psychedelics, as it is possible to spiral out of control during a trip.

FAQ

Does Mescaline Go Bad?

Like other substances, you should store mescaline in a dry, cold and oxygen-free environment. It is not as unstable as LSD so you shouldn’t be concerned that it will lose its potency. Mescaline doesn’t become toxic as it degrades. 

What Does Mescaline Taste Like?

All alkaloids taste bitter, and mescaline does too. If you take mescaline inside a capsule however then you won’t taste it. 

Is The Trip Between Pure Mescaline and Cacti Containing Mescaline Different?

Tripping on pure Mescaline and cacti-containing Mescaline, such as Peyote, San Pedro, or Peruvian Torch are relatively similar. However, the experiences will have very minor differences due to other alkaloids these cacti contain. In describing the difference between these cacti and pure Mescaline, users say that the cacti have less of a clear thought process. Meaning, you don’t know what you’re thinking about and why. This would be somewhat similar to the differences in effect between smoking cannabis flower and vaporizing a pure extract.

How Do I Test For Adulterants Within Mescaline?

An adulterant is an added substance that shouldn’t be there. It could be a residual chemical from a laboratory extraction or synthesis, or a less expensive compound added to pure mescaline in order to increase profitability. You can use a Marquis test to check for most common adulterants that could be in Mescaline. A Marquis is a chemical reagent test that produces specific colors when mixed with specific substances. While this won’t rule out all adulterants that could be in Mescaline, it will rule out most of them. Marquis tests are also a really inexpensive and quick way to test your substances, so this should be the minimum you do in ensuring your substances are pure.

Does Mescaline Carry Any Risk of Addiction?

According to Erowid, Mescaline will not cause physical dependencies and is unlikely to cause a psychological addiction. There hasn’t been a report thus far of someone who has experienced withdrawal symptoms. 

Contributor | Cort Honey

Disclaimer: Mescaline is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of this drug where it is prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore this substance. This guide is intended to give educational content and should in no way be viewed as medical recommendations.

If you have relevant information or updates concerning the research and studies of psychedelic substances, please reach out to info@realitysandwich.com We appreciate your contribution. –RS

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How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.

 

Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.

 

The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.

 

Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.

 

Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.

 

The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.

 

Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.

 

Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.

 

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.

 

Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.

 

Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.

 

Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.

 

Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?

 

Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.

 

Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.

 

Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

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