Powerful entheogenic substances were clearly utilized by the shamans and skywatchers working in the ancient Mayan city of Izapa. The profound integration of celestial, psychological, ritual, and mythopoeic elements found at Izapa bespeaks the psychedelic influence. Could the use of hallucinogens explain how the ancient skywatchers became aware of the Galactic Center? And what mysteries does the Galactic Center contain?