DMT Substance Guide: Effects, Common Uses, Safety

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DMT has one of the oldest histories of human use. Indigenous groups have been using it for upwards of over 4,000 years in the form of a brew with DMT and MAOI containing plants. It is found in a wide variety of plants, fungi, and animals–even humans naturally produce DMT.

Scientists believe the human body stores low quantities of DMT within the cerebrospinal fluid and could be produced in the eyes and lungs. The discovery of DMT within humans shed new light on how we understand the deep spiritual enlightenment so many people find during near-death experiences. The current belief is the body releases DMT during near-death experiences, causing strong hallucinations and radical, long-lasting shifts in perspective.

What You Will Learn About DMT

  • DMT is a core tryptamine that produces a profound psychedelic experience when consumed.
  • A DMT trip is a fully immersive experience when taken at a proper dosage resulting in strong closed and open eye visuals, as well as various other sensations.
  • Many users report life-changing spiritual experiences and extreme shifts in perspective after consuming DMT.
  • The DMT molecule is N, N-dimethyltryptamine.
  • The United Nations list DMT as a Schedule I substance under the Convention on Psychotropic Substances requiring all of its members to prohibit it.
  • DMT’s effects include strong open and closed eye visuals, a fully immersive experience, powerful sensations, radical shifts in perspective, life-changing spiritual experiences, an altered perception of time, slight discomfort of the stomach, fear, anxiety, and paranoia.
  • The visuals vary depending on the individual. However, some recurring visuals do occur such as the “Machine elves” Terence McKenna describes.
  • Some users develop HPPD or PTSD after a troubling psychedelic experience. While developing these conditions after consuming DMT is rare, some users do have difficulties with them.
  • DMT or other derivatives are found in over 400 species of plants and fungi.


As a naturally occurring tryptamine, derivatives of DMT can be found in at least 400 species of plants and fungi. Sometimes it is referred to as a core tryptamine because almost all substances belonging to the tryptamine class contain DMT’s chemical structure, psilocybin being the most popular. Chemists produce DMT both synthetically or through extraction, although extraction has become vastly more popular than synthesis due to costs. Typically users consume DMT by vaporizing it to a temperature of 160 degrees celsius, but can also be consumed intranasally or orally in combination with an MAOI. It usually takes the shape of a pure white or a pale yellow powdered crystal.

What is DMT?

DMT is a naturally occurring tryptamine with a chemical structure found in at least 400 species of plants and fungi. Almost all substances belonging to the tryptamine class of drugs contain DMT’s chemical structure. This is why it’s sometimes referred to as a core tryptamine. A tryptamine is a substance with a molecular structure that is a derivative of the tryptamine molecule. The tryptamine molecule in these structures is called a tryptamine backbone. This makes all psychoactive hallucinogenic tryptamines similar in effects with DMT and psilocybin being the most popular.

Street Name 

  • Spice
  • Changa
  • Dimitry
  • God molecule
  • Jim jam
  • Aya
  • Jungle spice

Scientific Name


N,N-Dimethyltryptamine—or DMT for short—is an alkaloid molecule classified as a tryptamine. There are two main ways of producing DMT: Extraction and Synthesis. Extraction methods vary greatly, but the most common method extraction is from plant material, particularly MHRB (mimosa hostilis root bark) and ACRB (acacia confusa root bark). These extractions potentially use dangerously strong bases and acids.

Forms & Ways of Consumption

It is a common misconception that DMT is consumed successfully by smoking. A direct open flame will cause it to burn and become inactive.

DMT comes in many shapes and sizes, and it is usually pale yellow-orange to pure white crystals when extracted. Oxidation, oils, and other tryptamines such as NMT can cause yellowing.

The most common forms of DMT include:

  • Fumarate
  • Freebase
  • Citrate
  • Acetate
  • Hydrochloride

All of these forms are a crystallized compound with different acids or bases used to bind the molecules together. Citrade, acetate, and hydrochloride are all DMT salts with a different acid used to produce the salt. These different forms require different methods of consumption.


Vaporized DMT must be in its freebase form, as there are theories that the salts release toxic compounds once heated. A common misconception surrounding vaporized DMT is that it is consumed successfully by smoking it with a direct open flame. Applying a direct open flame to freebase DMT causes it to burn and become inactive.

Instead, DMT becomes active when vaporized at a temperature around 160 degrees celsius (320°F).  Effects of vaporized DMT can be prolonged by mixing it in a smoking blend called changa, which typically contains plants that have MAOI or to which an MAOI has been added.

Users can also choose to snort it, which is much easier in its salt form, such as fumarate, citrate, or acetate, for better absorption through mucous membranes.


Another way of consuming DMT is orally in combination with a monoamine oxidase inhibitor, or MAOI. Users utilize this method of consumption in a variety of ways. One method involves cooking plants that contain these compounds together for hours. Some users simplify this by extracting the compounds and then consuming them in pill form, commonly referred to as pillahuasca, or “parachute” form. “Parachute” form is when a user places the substances inside thin paper, such as tissue paper, then swallows it. When using a pharmaceutical MAOI, it is referred to as pharmahuasca.

Many indigenous groups from the Amazon region consume a combination of DMT and MAOI by combining two plants, most often Banisteriopsis caapi (also called ayahuasca or just “caapi”), and psychotria viridis or alba (also known as “chacruna”) in a huge pot, where they then cook them while praying.

DMT Alternatives

Typically, Ayahuasca brews use Banisteriopsis caapi vines to provide MAOIs to the brew and another plant to provide the DMT. Recently, cultivators developed so-called psychotria nexus more adapted to live in colder climates as an alternative to B. caapi. Another option is using plants like Acacia confusa or Mimosa hostilis (Jurema) to provide the DMT and witheganum harmala (Syrian rue) for the MAOI.

A common alternative to pure DMT is 5-MeO-DMT. It produces a similar short-lasting intense psychedelic experience with only minor differences. 5-HO-DMT also produces a short-lasting psychedelic experience but has been associated with more negative effects such as tightness in the chest and throat, nausea, and numbness. Other chemicals such as psilocybin, psilocin, and 4-AcO-DMT also contain the DMT molecule within their chemical structure. However, these substances produce a significantly different psychedelic experience that can last upwards of 8 hours.

Are there any differences between original and alternative forms of DMT and Ayahuasca?

The difference will be in the taste and potency. There are some anecdotal reports that suggest that if DMT is a bit oily, it is actually stronger since it can also contain other alkaloids.

The community often refers to some of these “stronger forms” of DMT as Jimjam and Jungle spice. Jungle spice contains small amounts of DMT, but higher amounts of other alkaloids from mimosa hostilis.


Reality Sandwich DMT Dosage 1

Check out our dedicated dosage guide for more information about DMT dosage and microdosing.


DMT does not only naturally occur in plants and fungi, the human body also produces DMT. It can be found in small quantities within the cerebrospinal fluid and is thought to be produced in the lungs and eyes as well. The production of DMT likely results as a byproduct of the synthesis of melatonin and other tryptamines within the brain.

Although pure DMT was not synthesized until 1931, ancient use of ayahuasca traces back to at least 1,000 years ago. Scientists found a ritual bundle containing residue from Ayahuasca ingredients in southwestern Bolivia. Humans occupied this area for at least the last 4,000 years, so the use of ayahuasca could date even further back. These indigenous people likely used ayahuasca for spiritual rituals. These scientists also found evidence of cocaine and harmine use in this same location.. 

Some indigenous groups also used tobacco plants containing an MAOI to enhance the ayahuasca trip. This is a special kind of tobacco scientists call Nicotiana rustica. This kind of tobacco has no correlation with Nicotiana tabacum, found in commercial cigarette products.

History of Yopo

Anadenanthera peregrina, commonly referred to as yopo, was commonly used amongst indigenous people from Argentina, Peru, Colombia, Venezuela, Brazil, and Puerto Rico. Its use spans over four thousand years.

The fruit, beans, pods, and bark of the plant contain DMT and DMT based compounds such as 5-MeO-DMT and 5-HO-DMT. Traditionally, the beans of the plant were dried and smoked from pipes made from puma bone.

The first reports of yopo use date back to 1801 by a German explorer named Alexander Von Humboldt. He detailed how the Maipures of Orinoco prepared the A. peregrina seeds for use as a snuff. Essentially, they first roasted the seeds then placed them in a small wooden platter where they ground up the seeds to a fine powder with a pestle. Then they inhaled this powder through hollowed-out bird bones or bamboo tubes to experience the effects.

Did Masons Use DMT and Ayahuasca?

We can find references to Acacia plants (containing DMT) in many excerpts of Masonic literature, as it was fairly popular in Masonic circles up until the 1700s. In an allegory presented to all candidates of Freemasonry, Alessandro Cagliostro serves an ayahuasca-like brew containing Acacia to initiates in order to “raise” the candidates’ “spirits” before his lecture. Ayahuasca brew is a method of orally consuming DMT by brewing together a plant that contains DMT with a plant that contains an MAOI. The MAOI slows the body’s metabolism of DMT allowing it to become active within the body for an extended period of time.

The Scientific Breakthrough on DMT

In 1931, British Chemist Richard Helmuth Fredrick Manske became the first to synthesize DMT during his investigations into N-methyltryptamine, a compound biosynthesized by the human body. However, it wasn’t until 1955 that DMT was identified as an ingredient in A. peregrina seeds (used to make Yopo and cohoba snuffs) by a team of American scientists. This marked the first time DMT was documented as naturally occurring in a plant or animal. After this finding, speculation began to rise that it possessed psychoactive effects. The following year, in 1956, a scientific publication by Stephen Szara confirmed that it was indeed psychoactive.

Scientific studies (ranging from 1961 to 2015) have since discovered that mammalian lungs and brains synthesize DMT, as can human blood, urine, and cerebrospinal fluid. Some scientists believe the body releases this stored DMT during near-death experiences which results in the visions and spontaneous hallucinations people report during a near-death experience. Other individuals theorize that DMT is released during childbirth.

In December of 2000, Dr. Rick Strassman published DMT: The Spirit Molecule, where he summarized his academic work, experimental studies, and his own conclusions about the endogenous properties of DMT. After twenty years of pause from psychedelic research, Strassman was the first person in the US to undertake human research with psychedelic substances.

Laws and Legal Status

Is DMT Legal in the United States?

DMT is classified as a Schedule I drug under the United Nations 1971 Convention on Psychotropic Substances. However, this action did not regulate natural substances containing DMT, such as ayahuasca. In December of 2004, the United States Supreme Court lifted a stay allowing the Brazil-based União de Vegetal (UDV) church to use a tea containing DMT for their Christmas services that year.

Gonzales v. O Centro

Two years later, in Gonzales v. O Centro Espirita Beneficente Uniao do Vegetal, the court ruled that the federal government must allow the UDV to import and consume the tea for religious purposes under the 1993 Religious Freedom Restoration Act. After ruling in favor of the three Santo Daime churches, Judge Owen M. Panner issued a permanent injunction barring the government from penalizing or prohibiting the sacramental use of “Daime tea,” which contains ayahuasca.

In 2020, Oregon decriminalized all illegal drugs, including DMT.

Is DMT Legal in South America?

Law prohibits DMT in most countries. There are some exceptions for the DMT-containing ayahuasca, often for religious and spiritual purposes. However, possession and use of ayahuasca are legal in Brazil, which is why so many ayahuasca retreats exist in Brazil. Similarly, Peru is well-known for ayahuasca use, as it is legal to use and possess. Peru also offers ayahuasca retreats. There are no specific laws regarding DMT in Colombia, though ayahuasca is considered a religious sacrament and there are retreat centers available. The same goes for Costa Rica, Uruguay, and Ecuador. In many cases, DMT remains a controlled substance, whereas DMT-containing ayahuasca is considered acceptable for use in religious settings.

Is DMT Legal in Europe?

Although there are no laws prohibiting ayahuasca in Italy, there have been recent arrests of individuals using ayahuasca in the Santo Daime Church. Similarly to Italy, there is no specific law prohibiting ayahuasca in Spain. Despite this, arrests happen to members of the Santo Daime church for its use. All DMT-containing plants are illegal in France, and while Germany does not have specific ayahuasca laws, DMT is illegal under the German Narcotics Act.

Is DMT Legal in Netherlands or Amsterdam?

The Netherlands lists DMT as a Schedule I prohibited substance under the Opium Law. Ayahuasca became illegal on October 1st, 2019. This ruling came to power after a woman tried importing 33 kilos worth of ayahuasca brew across the border. After the decision of the lower court that she is guilty, she took the issue to the Supreme Court on the account that this would repress the religious freedoms. The Supreme Court, however, ruled that this was an infringement on public health making this an illegal act. It is still highly unlikely that an individual will be prosecuted for personal possession.

Is DMT Legal in Australia?

Currently, there are no specific laws that address ayahuasca in Australia. While there have been no prosecutions for ayahuasca, Australia has other harsh laws for other drugs, including DMT.


Mechanism of Action

DMT produces its psychedelic effects by binding to a wide range of serotonin, or 5-hydroxytryptamine, receptors in the central and peripheral nervous system. These receptors include the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, and 5-HT7 receptors. It may also bind to other serotonin receptors as well, but this has yet to be determined. DMT also acts as an agonist to the 5-HT1A, 5-HT2A, and 5-HT2C receptors.

Scientists believe the majority of DMT’s psychedelic effects stem from the strength of which it binds to the 5-HT2A receptor. 50% of its maximal effect is thought to be at the 5-HT2A receptor. The reason the 5-HT2A receptor is so important in producing a psychedelic experience is due to the way it acts as an inhibitor to the visual cortex and orbitofrontal cortex. This produces strong hallucinations as well as a loss of an individual’s sense of reality.


Before we can discuss whether or not DMT is toxic, we first need to define what makes a substance toxic. Toxicity is defined based on the levels of exposure required for a substance to cause harm to a human or animal. The level of toxicity is measured based on the dose required to cause harm to a human. Even water can be toxic in too high of a dose and lethal snake venom can be non-toxic in a small enough dose. LD50 is a common measurement of toxicity, which measures the lethal dose for half of the tested organisms.

Scientists consider this chemical toxic since it technically damages some cells and tissues after ingestion. But multiple studies have shown no connection between DMT and any kind of toxicity, even at high doses. 

There is some research that shows the neuro-regenerative and antidepressant effects of ayahuasca, along with some studies that indicate 5-MeO-DIPT, a DMT analog, is neurotoxic in rats. Some people within the psychedelic community speculate that this could mean other analogues are also neurotoxic. However, this has not been confirmed.


Anecdotal evidence suggests that users of DMT do not mix it with other substances besides an MAOI. It is recommended that users follow an MAOI diet before consuming an MAOI, as some foods and drinks can cause dangerous reactions. Some of these foods and drinks include aged cheese, yogurt, cured meats, fermented meats, certain types of alcoholic beverages, and others.Using any phenethylamines such as mescaline, 2CB or MDMA in combination with an MAOI can be extremely dangerous.

This combination potentially causes serotonin syndrome which can result in adverse effects and even death. People who have a history or family history of epilepsy or schizophrenic disorders are at an increased risk of seizure or a psychotic break when consuming any psychedelics.

TripSit Guide to Drub Combinations Chart


Evidence does not currently exist that DMT causes dangerous health effects in healthy individuals. However, more research must be conducted to determine whether or not DMT is a completely benign substance. The effects of DMT can cause an individual to stumble, fall over, and hurt themselves badly due to the way it causes a user to completely lose a sense of their body. Dangerous contamination of NaOH mixed with small particles of plant matter can also cause yellowing, and usually causes DMT to be brownish more than yellow. This can cause lung problems if taken by vapor, or stomach problems if consumed orally. Extremely challenging trips can leave a person with PTSD.

There is almost no evidence published about overdosing and DMT. However, according to the American Association of Poison Control DMT, use has been associated with coma and respiratory arrest. It has not been determined whether this was due to a combination of substances, pre-existing conditions, or DMT itself.

Common Side Effects

When taken by vaping, the effects of DMT typically lasts anywhere from 5 to 30 minutes. Unlike other hallucinogens, DMT will cause extremely strong visual hallucinations such as OEV (open eye visuals) and CEV (closed eyes hallucinations). Machine elves, as Terence McKenna would put it, sometimes occur as a common visual experience. Other common effects will depend on the individual, dosage, and set and setting, but generally include:

  • A fully immersive experience
  • Powerful sensations
  • Radical shifts in perspective
  • Life-changing spiritual experiences
  • Altered perception of time
  • Slight discomfort of the stomach
  • Fear, anxiety, and paranoia

As with other psychedelics, DMT is related to a condition known as hallucinogen persisting perception disorder (HPPD), which affects around 1% of all users of psychedelics. HPPD can manifest itself through visual snow similar to the static pattern seen on analog TVs when there is no signal coming through. However, this is not a major concern to the members of the community since it usually ceases over time. With that said, cannabis does seem to prolong this disorder.


Users report that DMT tolerance build-up is extremely low. In most cases, taking DMT one hour after the first vaporized intake will create effects on the same level as the first time. Ayahuasca tolerance is similar, but it can take up to a day for the tolerance to subside — possibly because of the MAOI content. Additionally, DMT does not cause cross tolerance, as is the case with LSD or Psilocybin, where the tolerance may be noticeable for up to a week after a single use.


How is DMT extracted?

A common method of extracting DMT utilizes a base such as lye dissolved in water. This base extracts DMT from a DMT containing the plant. Then, the extracted substance must be separated to ensure you are left with pure DMT. This usually uses Naptha mixed in the extraction to create two distinct layers, a clear layer and a darker one. The clear layer is the DMT and the dark layer is everything else that was extracted.

How long does DMT last?

DMT’s effects last for 5-30 minutes when smoked.

What does DMT look like?

The appearance of DMT consists of a white crystalline powder. Sometimes this powder will be tan due to leftover plant matter.

What is DMT found in?

DMT is found in a wide range of plants, fungi, and animals. Even humans naturally produce DMT.

How is DMT made?

Synthesizing DMT involves the reaction of indole with oxalyl chloride followed by a reaction with dimethylamine and a reduction with lithium aluminum hydride.

What does DMT stand for?

DMT stands for N,N-dimethyltryptamine

Why is DMT illegal?

Most developed countries consider DMT a public health hazard.

Where is DMT legal?

The United Nations list DMT as a Schedule I drug under the Convention on Psychotropic Substances which requires all members prohibit the substance. However, Ayahuasca is legal in Brazil and Peru.

What does DMT do in my body?

It binds to a wide variety of serotonin receptors causing a psychedelic experience.

How long does a DMT trip last?

A DMT trip lasts for 5-30 minutes when smoked. If consumed in an Ayahuasca brew, the effects can last for up to 8 hours.

What does DMT feel like?

DMT causes a fully immersive psychedelic experience resulting in closed and open eye hallucinations, as well as a variety of other sensations.

What plants contain DMT?

Over 400 different species of plants and fungi contain the DMT molecule or a derivative of the DMT molecule.

When is DMT released naturally?

Scientists are still unclear of when the body releases DMT, but they currently believe the body releases it during near-death experiences.

How Long Does DMT Stay in Your Body?

DMT stays in your system for a short amount of time due to enzyme monoamine oxidase, which destroys it quickly after ingestion/inhalation. However, the consumption of the MAOI can increase the duration of the effects and longevity of this molecule. 

How do you extract DMT from frogs?

The extraction of DMT does not come from frogs. However the similar substances 5-MEO-DMT and 5-HO-DMT come from the skin of Incilius alvarius. The more common name for this species is the Colorado River Toad. 5-MEO and 5-HO are NOT good substitutions for DMT, as they are more potent and orally active. There are only one species of frogs that causes hallucinations, the Phyllomedusa bicolor. Evidence has also shown that extracting 5-MEO-DMT and 5-HO-DMT from frogs is harmful to the ecological health of the species.

Do all frogs make DMT?

No, frogs do not make DMT. Toads do. Not all toads produce it.

What’s the difference between Synthetic or toad?

Essentially no difference exists between naturally occurring (extracted) and synthetic DMT. They can both be dangerous if not prepared and extracted properly.

Does DMT degrade?

It can oxidize over time and become less potent, but there are conflicting claims about this in the community.

Disclaimer: DMT is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of this drug where it is prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore this substance. This guide is intended to give educational content and should in no way be viewed as medical recommendations.

If you have relevant information or updates concerning the research and studies of psychedelic substances, please reach out to We appreciate your contribution. –RS

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Changa vs. DMT: What You Need to Know
While similar (changa contains DMT), each drug has its own unique effect and feeling. Let’s compare and contrast changa vs DMT.

5-MeO-DMT Guide: Effects, Benefits, Safety, and Legality
5-Meo-DMT comes from the Sonora Desert toad. Here is everything you want to know about 5-Meo-DMT and how it compares to 4-AcO-DMT.

4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality
This guide tells you everything about 4 AcO DMT & 5 MeO DMT, that belong to the tryptamine class, and are similar but slightly different to DMT.

How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.


Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.


The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.


Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.


Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.


The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.


Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.


Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.


Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.


Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.


Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.


Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.


Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?


Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.


Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.


Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

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