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Ketamine Resources, Studies, and Trusted Information

Ketamine Resources

Table of Contents

Ketamine was initially developed as a surgical anesthetic in the 1960s, and shortly thereafter found use as a field anesthetic in the Vietnam War. Over the ensuing decades, it was deemed a WHO Essential Medicine, providing effective anesthesia, analgesia and sedation in clinics and hospitals around the world. In recent years, however, there has been an explosion of interest in using ketamine for mental health conditions, psychotherapeutic work and psycho-spiritual exploration. 

Notably, on the psychiatric front, the FDA approved the first ketamine-related treatment in 2019 for severe depression, and racemic ketamine continues to be successfully used off-label for depression and other disorders across hundreds of legal clinics around the country. While antidepressants work for some, many others find no relief. Accordingly, a booming psychedelic ketamine industry has sprung up. Ketamine for depression has ushered in a new paradigm for treatment-resistant depression. This article contains ketamine resources for those interested in learning more about the drug and treatment, covering recreational ketamine use, ketamine infusion therapy, and ketamine-assisted psychotherapy. 

Reality Sandwich Articles on Ketamine

Below is a list of articles centered around ketamine that have been published on Reality Sandwich since 2016: 

Clinical Trials/Studies

Ketamine was first investigated as a treatment for depression at Yale University in 2000 — a landmark study that showed a rapid antidepressant effect that persisted for at least three days. Since that first clinical trial, dozens of clinical trials and case reports have followed in support of its antidepressant efficacy. More recently, accumulating evidence suggests ketamine is a promising treatment approach for several other mental health conditions, including bipolar depression, anxiety, PTSD, OCD, and substance use disorders. Below is a curated list of clinical trials, studies and systematic reviews on ketamine’s uses in psychiatry and its mechanisms of action in the brain.

Treatment-resistant Depression (TRD)

Bipolar Depression 

Suicide Prevention


Post-Traumatic Stress Disorder (PTSD) 

Obsessive-Compulsive Disorder (OCD)

Substance Use Disorder Studies

Ketamine Psychedelic Therapy

Mechanism of Action


The following list of books cover ketamine science and history, its clinical and therapeutic uses, ketamine treatment information, as well as personal accounts and interpretations of the ketamine experience.

Documentaries and Videos

Clinics and Integration Therapists

Ketamine Clinics

With the psychiatric establishment embracing ketamine as a powerful tool to fight severe mood disorders and chronic pain over recent years, a variety of legal ketamine clinics have sprung up around the country. These clinics are the first legal psychedelic therapy, offering intravenous infusions of off-label racemic ketamine with a treatment plan personalized to each patient. 

A comprehensive list of ketamine providers in the United States and internationally can be found on the KRIYA Institute website here. In addition, anyone can explore treatment options on the Ketamine Clinics Directory website, which offers an updated map of US-based ketamine treatment centers and top-rated clinics by state. 

Choosing a ketamine clinic can be difficult, with many factors to consider beyond pricing alone. This includes the facility location, the treatment setting, the provider credentials and support staff, the protocols used and more. Be sure to consult past client testimonials on Yelp, Google and Facebook to ensure the clinic is reputable and to evaluate possible strengths and weaknesses before moving forward with treatment. 

When it comes to pricing, ketamine infusions typically carry a price tag of $400-800 dollars. Being off-label, and therefore not FDA approved, ketamine infusions are commonly denied coverage by insurance. Be sure to talk with your insurance and prospective provider about the extent of coverage before moving forward with the treatment.

Ketamine-Assisted Psychotherapy

Ketamine-assisted psychotherapy (KAP) is a legal healing approach that utilizes ketamine as an adjunct to enhance the psychotherapeutic process. Ketamine can soften the ego defenses (otherwise known as ego death), allowing difficult material to be processed for deeper healing. This is a good option for those who gained little to no benefit from conventional approaches. Integration follow-up sessions are provided by the clinician following the ketamine-assisted sessions.

For more information on KAP and recommended clinicians in California, consult these links:

For integration support outside of a KAP context, consult these resources:

  • MAPS Psychedelic Integration List – A comprehensive list of international and US-based psychedelic integration therapists.
  • Psychedelic Support Network – A list curated by Psychedelic Support of credentialed integration therapists offering services, such as pre-and post-ritual counseling and individual and group psychedelic integration.


Dylan is a freelance science writer and editor based in the beautiful Pacific Northwest. After finishing his physics degree and dabbling in neuroscience research at UC Santa Barbara in 2017, he returned to his first love—writing. As a long-term fan of the human brain, he loves exploring the latest research on psychedelics, nootropics, psychology, consciousness, meditation, and more. When he’s not writing, you can probably find him on hiking trails around Oregon and Washington or listening to podcasts. Feel free to follow him on Insta @dylancb88.

Disclaimer: Ketamine is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of these drugs where prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore these substances. This guide is intended to give educational content and should in no way be viewed as medical recommendations.

Ketamine Resources

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.


What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.


Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.


Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.


Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.


Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.


Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.


Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.


Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.


Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this "dissociative anesthetic" and how it is being studied for depression treatment.


Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.


Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.


Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.


How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.


How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.


How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it's legal to buy ketamine, and if it's possible to purchase legal ketamine on the internet.


How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!


How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.


Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.


Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!


K-Cramps: Complications of Ketamine Overuse
What are k-cramps, and how can you avoid them during your next ketamine trip? Read this guide to learn more.

Single Ketamine Infusion: Medicinal Benefits & Dosage
Do you need a series of ketamine treatments to be effective or is a single ketamine infusion beneficial? Read to learn more.

Goodbye Alcohol, Hello Ketamine
New study shows that even one dose of ketamine can help heavy drinkers reduce their alcohol intake. Read here to learn more!

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