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Ketamine Resources, Studies, and Trusted Information

Ketamine Resources
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Ketamine was initially developed as a surgical anesthetic in the 1960s, and shortly thereafter found use as a field anesthetic in the Vietnam War. Over the ensuing decades, it was deemed a WHO Essential Medicine, providing effective anesthesia, analgesia and sedation in clinics and hospitals around the world. In recent years, however, there has been an explosion of interest in using ketamine for mental health conditions, psychotherapeutic work and psycho-spiritual exploration. 

Notably, on the psychiatric front, the FDA approved the first ketamine-related treatment in 2019 for severe depression, and racemic ketamine continues to be successfully used off-label for depression and other disorders across hundreds of legal clinics around the country. While antidepressants work for some, many others find no relief. Accordingly, a booming psychedelic ketamine industry has sprung up. Ketamine for depression has ushered in a new paradigm for treatment-resistant depression. This article contains ketamine resources for those interested in learning more about the drug and treatment, covering recreational ketamine use, ketamine infusion therapy, and ketamine-assisted psychotherapy. 

Table of Contents

  • Reality Sandwich Articles on Ketamine
  • Clinical Trials/Studies
  • Books
  • Documentaries and Videos
  • Retreats and Integration Therapists

Reality Sandwich Articles on Ketamine

Below is a list of articles centered around ketamine that have been published on Reality Sandwich since 2016: 

Clinical Trials/Studies

Ketamine was first investigated as a treatment for depression at Yale University in 2000 — a landmark study that showed a rapid antidepressant effect that persisted for at least three days. Since that first clinical trial, dozens of clinical trials and case reports have followed in support of its antidepressant efficacy. More recently, accumulating evidence suggests ketamine is a promising treatment approach for several other mental health conditions, including bipolar depression, anxiety, PTSD, OCD, and substance use disorders. Below is a curated list of clinical trials, studies and systematic reviews on ketamine’s uses in psychiatry and its mechanisms of action in the brain.

Treatment-resistant Depression (TRD)

Bipolar Depression 

Suicide Prevention


Post-Traumatic Stress Disorder (PTSD) 

Obsessive-Compulsive Disorder (OCD)

Substance Use Disorder Studies

Ketamine Psychedelic Therapy

Mechanism of Action


The following list of books cover ketamine science and history, its clinical and therapeutic uses, ketamine treatment information, as well as personal accounts and interpretations of the ketamine experience.

Documentaries and Videos

Clinics and Integration Therapists

Ketamine Clinics

With the psychiatric establishment embracing ketamine as a powerful tool to fight severe mood disorders and chronic pain over recent years, a variety of legal ketamine clinics have sprung up around the country. These clinics are the first legal psychedelic therapy, offering intravenous infusions of off-label racemic ketamine with a treatment plan personalized to each patient. 

A comprehensive list of ketamine providers in the United States and internationally can be found on the KRIYA Institute website here. In addition, anyone can explore treatment options on the Ketamine Clinics Directory website, which offers an updated map of US-based ketamine treatment centers and top-rated clinics by state. 

Choosing a ketamine clinic can be difficult, with many factors to consider beyond pricing alone. This includes the facility location, the treatment setting, the provider credentials and support staff, the protocols used and more. Be sure to consult past client testimonials on Yelp, Google and Facebook to ensure the clinic is reputable and to evaluate possible strengths and weaknesses before moving forward with treatment. 

When it comes to pricing, ketamine infusions typically carry a price tag of $400-800 dollars. Being off-label, and therefore not FDA approved, ketamine infusions are commonly denied coverage by insurance. Be sure to talk with your insurance and prospective provider about the extent of coverage before moving forward with the treatment.

Ketamine-Assisted Psychotherapy

Ketamine-assisted psychotherapy (KAP) is a legal healing approach that utilizes ketamine as an adjunct to enhance the psychotherapeutic process. Ketamine can soften the ego defenses (otherwise known as ego death), allowing difficult material to be processed for deeper healing. This is a good option for those who gained little to no benefit from conventional approaches. Integration follow-up sessions are provided by the clinician following the ketamine-assisted sessions.

For more information on KAP and recommended clinicians in California, consult these links:

For integration support outside of a KAP context, consult these resources:

  • MAPS Psychedelic Integration List – A comprehensive list of international and US-based psychedelic integration therapists.
  • Psychedelic Support Network – A list curated by Psychedelic Support of credentialed integration therapists offering services, such as pre-and post-ritual counseling and individual and group psychedelic integration.


Dylan is a freelance science writer and editor based in the beautiful Pacific Northwest. After finishing his physics degree and dabbling in neuroscience research at UC Santa Barbara in 2017, he returned to his first love—writing. As a long-term fan of the human brain, he loves exploring the latest research on psychedelics, nootropics, psychology, consciousness, meditation, and more. When he’s not writing, you can probably find him on hiking trails around Oregon and Washington or listening to podcasts. Feel free to follow him on Insta @dylancb88.

Disclaimer: Ketamine is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of these drugs where prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore these substances. This guide is intended to give educational content and should in no way be viewed as medical recommendations.


  • Reality Sandwich

    Life is Psychedelic. Reality Sandwich serves you the most up to date information on psychedelic science, art, culture, news and substances. Knowledge is power, have a bite!

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