NOW SERVING Psychedelic Culture

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Lysergic acid diethylamide (LSD) was born in a lab in Basel, Switzerland in 1938. Dr. Albert Hofmann worked at Sandoz Pharmaceuticals when he synthesized LSD while intending to create a blood stimulant. It was several years later that he discovered its hallucinogenic properties. For the next couple of decades, psychiatrists used LSD to study behavioral and personality changes and to treat addiction, depression, and psychosomatic disease. The government took an interest in LSD’s potential as a truth serum, and the CIA performed their own experiments. However, researchers didn’t unlock this psychedelic drug’s full potential before the U.S. government banned its use in the late ‘60s.

Retreating to the underground, LSD — or acid, for short — became a popular drug that left a massive imprint on Western culture. Over the last several years, psychedelic use is surging for its touted wellness benefits. Research is beginning to show that there may be a medicinal component to psychedelics, and scientists, writers, researchers and psychonauts are all chiming in. Explore the following LSD Resources and discover books, movies, studies and more related to LSD.

Reality Sandwich Articles on LSD

Below is a list of articles relating to LSD published in Reality Sandwich since 2010:

Clinical Trials and Studies

Though LSD was once used to study psychological behaviors, its perfect medical use was never fully discovered. Now, scientists and researchers are taking another look at the science behind this drug. The renewed interest in the potential uses of LSD in pharmacology has many universities and hospitals performing in-depth studies with participants looking to treat depression, reduce alcohol use, and even study LSD’s effects on the experience of listening to music.

University Hospital, Basel, Switzerland

The city where LSD was born is still just as interested in the pharmacological benefits of LSD and its effects on the human brain. The University Hospital is currently conducting many trials, including the following:

  • LSD Therapy for Persons Suffering From Major Depression (LAD) — This study began in 2019 and is running until 2023. Sixty people have volunteered to participate in this study that will use randomized, double-blind, active-placebo-controlled trials. The measurable outcomes will show whether or not there is a change in symptoms of depression, anxiety, and general psychopathology. 
  • Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin (LSD-psilo) — This study began in 2019 with 30 participants and was estimated to conclude in April 2021. Its purpose is to compare the functionality of LSD and psilocybin when it comes to waking consciousness and brain activity. While the drugs are similar in their effect, this clinical trial aims to study the effects of both substances side by side as pharmacological tools for the field of neuroscience.

John Hopkins Center for Psychedelic & Consciousness Research

Known as the leading psychedelic research institute in the U.S., the John Hopkins Center for Psychedelic & Consciousness Research has published over 60 peer-reviewed studies in many scientific journals. Their research focuses on a wide range of psychedelic drugs and their therapeutic uses for several conditions, such as alcoholism and treatment-resistant depression. Some of their articles include:

  • Cessation and reduction in alcohol consumption and misuse after psychedelic use — A 2019 study showing how alcohol use decreased in study participants after taking a dose of LSD. This was evidenced by the 83% of participants who no longer showed signs of alcohol use disorder (AUD) after the trials. Furthermore, the participants claimed the experience was significant and insightful.
  • LSD enhances the emotional response to music — A study intent on discovering whether or not LSD has the ability to affect the human response to music. Ten volunteers consumed LSD and/or a placebo and listened to multiple tracks of music. The participants who consumed the LSD reported feelings of “wonder,” “transcendence,” “power” and “tenderness.”


This list includes historical books about the creation and use of LSD and personal viewpoints of the culture surrounding LSD, and touches on other psychedelics.

Documentaries and Videos

  • Ergot: The Story of a Parasitic Fungus — A 1950s documentary delving into the history of ergot, including its medical and commercial use. This fungus contains lysergic acid, the known precursor to LSD.
  • History of the Hallucinogen LSD ACID — Encyclopedia Britannica Educational Films takes an interesting look at the history of LSD, and even highlights how little science understood this drug, bringing to light some of the original propaganda surrounding LSD. 
  • The Sunshine Makers — The story of Nicholos Sand and Tim Scully, the manufacturers behind Orange Sunshine, one of the most famous kinds of LSD ever made, further fueling the 1960s drug culture.
  • Inside LSD — A 2012 National Geographic documentary that dives into new research on LSD and what kind of positive results are being discovered.  
  • Hofmann’s Potion — A 2012 documentary looking at LSD’s troubled past for medicinal use, while exploring where it could provide a hopeful future for medicine. 
  • Have a Good Trip: Adventures in Psychedelics — Netflix released this star-studded 2020 documentary that shares funny, insightful, and sometimes mind-blowing stories about psychedelic use with substances such as LSD.
  • The Art of Acid — A documentary exploring The Institute of Illegal Images at Mark McCloud’s home. McCloud holds the world’s largest collection of LSD blotter art. 
  • The Substance: Albert Hofmann’s LSD — A 2011 documentary that covers LSD, spanning from its inception up to the date of filming. The film explores how perceptions of LSD have evolved, and how ideas about the benefits of LSD have changed over time.
  • Neurons to Nirvana: Understanding Psychedelic Medicines — A 2013 documentary featuring interviews with researchers, writers and psychologists about the potential medicinal benefits of five powerful psychedelic drugs, including LSD.
  • Psychedelics and the History of LSD — A brief video explaining the history of LSD, how it was discovered and initially used, and what it became in the following decades.

Retreats and Integration Therapists

Currently, LSD is illegal in most countries and there are no publicly known LSD-specific retreat centers. However, many resources are available for those who have used LSD and are looking for beneficial integration tools. Among them are the following:

For a complete list of psychedelic resources made available by author Michael Pollan, visit his resource guide. Do you have any LSD resources that have been helpful in your journey? Drop a comment below and let us know what to include. Subscribe to the Reality Sandwich newsletter and never miss a bite of psychedelically inspired news.

Disclaimer: LSD is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of this drug where prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore such substances. This guide is intended to give educational content and should in no way be viewed as medical recommendations.

LSD Resources

How Much Does LSD Cost?
When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.


Navy Use of LSD on the Dark Web
The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.


Having Sex on LSD: What You Need to Know
Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.


A Drug That Switches off an LSD Trip
A pharmaceutical company is developing an "off-switch" drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.


Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD
The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.


LSD Guide: Effects, Common Uses, Safety
LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?


Microdosing LSD & Common Dosage Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.


LSD Resources
Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.


LSD as a Spiritual Aid
There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.


Legendary LSD Blotter Art: A Hidden Craftsmanship
Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.


LSD and Exercise: Does it Work?
LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.


Jan Bastiaans Treated Holocaust Survivors with LSD
Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.


LSD and Spiritual Awakening
I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a "knower of hearts."


How LSD is Made: Everything You Need to Know
Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.


How to Store LSD: Best Practices
Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.


Bicycle Day: The Discovery of LSD
Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.


Cary Grant: A Hollywood Legend On LSD
Cary Grant was a famous actor during the 1930's-60's But did you know Grant experimented with LSD? Read our guide to learn more.


Albert Hofmann: LSD — My Problem Child
Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.


Babies are High: What Does LSD Do To Your Brain
What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult's brain on LSD looks like a baby's brain.


1P LSD: Effects, Benefits, Safety Explained
1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.


Francis Crick, DNA & LSD
Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?


What Happens If You Overdose on LSD?
A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.


How To Get LSD
How can you get LSD? Are there specific ways to access this psychedelic? Read on to learn more about how to get LSD.

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