Methoxetamine (MXE) Guide: Effects, Uses, Legality, and Safety

Methoxetamine (MXE) Guide: Effects, Uses, Legality, and Safety

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Methoxetamine (MXE) is a dissociative anesthetic with effects similar to ketamine. Popularized in 2010, MXE is a relatively new synthetic designer drug. Designer drugs have effects that resemble their controlled analogs while evading legal bans and standard detection methods. 

Similar to ketamine, MXE is an NMDA antagonist but differs in that it is more potent, longer-lasting, and also acts as a serotonin reuptake inhibitor. Preclinical trials suggest that MXE possesses potent antidepressant and analgesic properties, but further research is needed to better understand its pharmacological properties, mechanisms, and safety profile.

Table of Contents

  1. Overview
  2. History
  3. Legality
  4. Pharmacology
  5. Effects
  6. Uses
  7. MXE Today
  8. MXE FAQ

1. Overview 

What is MXE?

Methoxetamine is a research chemical with dissociative and psychedelic properties similar to ketamine and phencyclidine (PCP). It was originally developed by an underground chemist in the UK as an allegedly safer alternative to ketamine. Since ketamine is an established, rapid-acting antidepressant, MXE is believed to possess similar antidepressant and analgesic properties. On these fronts, MXE may have therapeutic potential for major depression and a variety of pain syndromes such as phantom limb syndrome.

Street Names

  • MXE
  • Mexxy
  • M-ket
  • Kmax
  • Special M
  • MA
  • Legal ketamine
  • Minx
  • Jipper
  • Roflcoptr

Methoxetamine (MXE)

Methoxetamine, also known as 3-MeO-2′-oxo-PCE, is an eticyclidine (PCE) derivative and structural analog of ketamine. Methoxetamine is a contraction of “methoxy-ketamine”. The name refers to a methoxy group that replaced a chloro group in the chemical structure of ketamine. 

Like ketamine and PCP, MXE belongs to a family of compounds known as the arylcyclohexylamines. The name refers to their molecular structure, which is composed of an aryl group bound to a cyclohexylamine unit. They are a broad group of pharmaceutical and designer drugs known for their dissociative, anesthetic, and psychedelic properties due to their shared mechanism of action as NMDA antagonists.

Like ketamine, MXE contains two stereoisomers. Stereoisomers are compounds with the same molecular formula but differ in the spatial arrangement of their atoms. MXE is found on the gray market largely as the racemic mixture, though enantiopure batches (batches of only 1 of the 2 stereoisomers) have been distributed.

Ways to Consume MXE

Methoxetamine is typically found in powder form as a white or off-white hydrochloride salt. It is administered in a multitude of forms, including:

  • Oral (capsules or dissolved in solution)
  • Sublingual
  • Nasal insufflation
  • Intramuscular injection
  • Intravenous injection
  • Rectal

Each route produces a different onset of action, duration, and intensity of effects.

2. History 

Circa 2008, MXE was developed by an underground chemist based in the United Kingdom. By May of 2010, MXE began receiving online exposure on several drug forums. A few months later, in September of 2010, it began to be commercially available on a small scale. 

Methoxetamine maintained growing popularity among the Internet and drug forum members as its distribution in the gray market accelerated. This eventually led to its identification by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in November of 2010, which recognized 58 websites offering MXE by the next year. 


The chemist who created MXE was interviewed by Hamilton Morris in the February 2011 edition of Vice Magazine. He identified himself as the anonymous pharmaceutical chemist “M.” 

M. suffered chronic, severe phantom limb pain following the amputation of his left hand when he was a teenager. This experience largely fueled his interest in altered states and his search for better analgesics. Apart from his experiences with ketamine and cannabinoids, all of the analgesics he was prescribed had little to no effect on his phantom limb pain.

After academic training in biochemistry and neuropsychopharmacology, he transitioned into independent pharmaceutical research. Here, M. began research investigating arylcyclohexylamines like PCP and ketamine, intrigued by their dual-use as pain relievers and antidepressants. After having the idea of MXE “floating around [his] head for about three years”, he found someone that could finally produce a small batch. 

As explained in his interview, the concept of MXE was birthed by “tweaking” ketamine at several functional groups in the chemical structure. The 2-chloro group on the phenyl ring was replaced with a 3-methoxy group. The 3-methoxy group purportedly gives MXE weaker analgesic and anesthetic properties compared to ketamine. The N-methyl group on the amine was replaced with an N-ethyl group. The N-ethyl was chosen to give MXE a longer duration of action and increased potency relative to ketamine. 

With these structural changes in mind, M. deemed MXE a “stress-free version of ketamine” and eventually began using it successfully to treat his phantom limb pain. As M. states in the Vice interview, “The arylcyclohexylamines have a tremendous therapeutic potential, but they have a great abuse potential as well.” He learned the latter directly after injecting a high dose of MXE and ending up hospitalized, which led to the subsequent confiscation of the arylcyclohexylamine compounds he was researching.

3. Legality

The legality of Methoxetamine began to be heavily examined following its introduction to the gray market in 2010. In this section, we will overview where MXE is currently legal and not, as well as key laws that have been passed to control its purchasing, sale, and possession.

Where is MXE legal?

As of this writing, MXE is federally unscheduled in the United States. However, several states have added it to to the list of schedule I controlled substances, making it illegal to buy, sell, or possess. This includes:

  • Alabama
  • Florida
  • Indiana
  • Minnesota
  • North Dakota
  • Ohio
  • Virginia
  • Utah

Being an analog of a controlled substance, MXE is illegal to purchase, sell, or possess for human consumption according to the Federal Analogue Act. This has been avoided by the placement of “not for human consumption” on the chemical packaging.

Internationally, Methoxetamine has been categorized as a controlled substance in several countries, including:

  • Brazil
  • China
  • Canada
  • Croatia
  • Cyprus
  • Denmark
  • France
  • Germany
  • Israel
  • Netherlands
  • Poland
  • Slovenia
  • Sweden
  • Japan 
  • Russia
  • Switzerland
  • Turkey
  • United Kingdom

Laws Passed

In April of 2012, Methoxetamine was placed under temporary class drug control in the United Kingdom, which prohibited the sale and import within the country for one year. After suggestions by the EMCDDA, it was permanently added to the Class B drug list in February of 2013, This category also includes amphetamines, cannabis, and ketamine.

In June of 2014, the European Union designated MXE a controlled substance after a risk assessment by the EMCDDA. This effectively outlawed MXE in European Union member states.

In November of 2016, MXE has been controlled as a schedule II substance under the UN 1971 Convention on Psychotropic Substances, a United Nations treaty designed to control psychoactive substances. Schedule II includes substances with therapeutic uses such as THC, amphetamine, and methylphenidate

4. Pharmacology 

Mechanism of Action

The mechanism of action of MXE overlaps with ketamine, but several differences account for its varying effects. Similar to ketamine, MXE antagonizes the glutamatergic N-methyl-D-aspartate (NMDA) receptor. It binds to the NMDA receptor at the phencyclidine site, an action that’s thought to be responsible for its potent dissociative properties.

Unlike ketamine, however, MXE also binds to the serotonin transporter, acting as a serotonin reuptake inhibitor. This mechanism of action is shared with prescription monoamine-based antidepressants and may in part underlie its antidepressant action. 

In addition, MXE shows a weak affinity for the dopamine and norepinephrine transporters. Its ability to enhance dopaminergic neurotransmission, especially in the mesolimbic dopamine reward pathway, is thought to confer its high abuse liability. On the other hand, its ability to enhance norepinephrine signaling may account for its stimulatory and peripheral effects.


There is a lack of human studies investigating the toxicity of Methoxetamine, so most of the data come from animal studies and case study reports. According to a 2015 report by the World Health Organization, MXE has been associated with 120 non-fatal intoxications. These hospitalizations were due to either high dosages of MXE or drug-drug interactions with other psychoactive substances.

MXE has been advertised as a “bladder friendly” analog of ketamine. It has been speculated that its increased potency would limit the urotoxic metabolites that are commonly associated with chronic ketamine use. However, these claims have not been substantiated in preclinical animal studies. In one 2014 study, mice were administered a large daily dose of MXE (30mg/kg) for three months, resulting in significant damage to the urinary tract. This was seen as bladder inflammation and fibrosis as well as renal toxicity. 


MXE is known to potently synergize and potentiate the effects of other substances. Users should be cautious and conduct independent research to minimize negative drug-drug interactions. 

Central nervous system depressants such as benzodiazepines, alcohol, opiates, GHB, and GBL should be avoided with MXE consumption. These can lead to dangerous synergistic effects that can amplify the depressant effects on movement, breathing, and consciousness.

Central nervous system stimulants such as amphetamine, methylphenidate, and cocaine can also cause negative interactions with Methoxetamine. These combinations can induce manic states and create potentially dangerous side effects by further increasing heart rate and blood pressure. 

Serotonergic substances, including MDMA and SSRIs, may increase the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening neurotoxic reaction caused by an excess of serotonin in the body. 

Taking MXE with cannabinoids (natural or synthetic) and hallucinogens have been reported to induce intense entheogenic experiences, but other reports mention these combinations can increase the chance of negative psychological effects, including fear, panic attacks, paranoia, and intense hallucinations.

Common MXE Dose

A common dose range for MXE is 40-60 mg by oral administration, 20-60 mg by nasal insufflation, and 15-30 mg by intramuscular injection. However, these dose ranges are tentative, given the wide dose ranges used and high variability in effects from person to person. The effects are typically apparent 10-90 minutes later, depending on the route of administration. 

Oral10-30 mg40-60 mg50-100+ mg
Intranasal10-50 mg20-60 mg25-100+ mg
Intramuscular5-20 mg15-30 mg20-80+ mg

Owing to the long onset of action and rewarding effects, many individuals report compulsive dosing or a strong urge to redose. Redosing can result in the consumption of more than initially planned, potentially leading to dangerous cumulative effects and overdose.


According to the WHO, there are over 20 reported deaths due to methoxetamine overdose. In these fatal cases, other substances were combined with MXE, including amphetamines, MDMA, cocaine, alcohol, synthetic cannabinoids, and benzodiazepines. 

According to case studies, MXE overdoses have resulted in acute cerebellar toxicity, seen as incoordination, nystagmus, and reduced conscious level, which resolved over a period of 1-4 days. 

MXE overdose is associated with depressive symptoms such as slow heart rate, respiratory depression, catatonia, and loss of consciousness. Stimulant effects have been reported in an MXE overdose, including agitation, aggression, tachycardia, and hypertension.  A number of negative psychological effects have also been reported in an overdose. This includes anxiety, panic attacks, paranoia, confusion, disorientation, and intense hallucinations.


Due to MXE’s limited history of use and lack of human research, not much is known about its long-term safety. It is believed to be moderately addictive because it activates the reward circuitry in the brain. Anecdotal evidence suggests that compulsive use and habit formation are both common, as well as unpleasant withdrawal symptoms after prolonged use. The vast majority of intoxications and deaths have resulted from high doses and combinations with other substances (reference previous section “Interactions”). 

When taken alone and moderately within a common dose range, the greater risk of harm or death arises from improper set and setting. Having a safe trip area and a sitter can prevent accidents such as falls and reduce undesirable psychological effects.

5. Effects 

Being a young research chemical, MXE’s effects have not been parsed out in clinical trials. Much of what is known is based on anecdotal reports over the last decade. With this in mind, the MXE trip may be very different from person to person depending on the dose, set and setting, and route of administration. 

How Long Does MXE Last?

MXE’s duration of effects depends on the route of administration. Intravenous or intravenous injections lead to the quickest onset and shortest duration. If it is orally or sublingually administered, the MXE high is more gradual and lasts longer. 

OnsetDurationAfter Effects
Intranasal 10-20 minutes2.5-4 hours2-48 hours
Sublingual10-20 minutes3-5 hours2-48 hours
Intramuscular2-10 minutes2-3 hours2-48 hours

Physiological Effects

The probability of adverse physiological effects increases with increasing dose. This may include:

  • Sweating
  • Analgesia (numbness)
  • Spontaneous bodily sensations
  • Increased or irregular heart rate
  • Increased blood pressure
  • Vertigo
  • Nausea
  • Vomiting
  • Loss of motor coordination
  • Slurred speech
  • Respiratory depression

Psychological Effects

Common psychological effects include:

  • Euphoria
  • Feelings of peacefulness and calmness
  • Rapid antidepressant effects 
  • Enhanced introspection and self-reflection
  • Increased empathy
  • Enhanced sociability
  • Intensification of sensory experiences (e.g. music sounds better)
  • Vivid recall of memories and dreams

At high doses, MXE produces effects that resemble a Near Death Experience (NDE), including:

  • Intense out-of-body experiences
  • “M hole” (total dissociation of mind from the body)
  • Perceptual distortions (dramatically altered sense of time and distance)
  • Distortion of body image (feelings of floating, heaviness, or lightness)
  • Vivid auditory and visual hallucinations 
  • Spiritual and transcendent experiences (sense of unity and interconnectedness)

Common Side Effects

MXE is associated with a multitude of undesirable side effects, especially at high doses. Physiologically, this includes:

  • Slurred speech
  • Ataxia (impaired balance and coordination)
  • Analgesia (numbness)
  • Sweating
  • Nausea 
  • Vomiting 

Psychological adverse effects may include:

  • Depersonalization and derealization
  • Confusion
  • Impaired understanding of language
  • Disorientation
  • Loss of concentration and attention span
  • Drowsiness
  • Anxiety
  • Fear
  • Paranoia
  • Psychomotor agitation
  • Loss of consciousness


While little data exists on MXE’s potential for physical dependence, users have reported compulsive use and psychological dependence. Psychological dependence is compounded by the development of tolerance, where users have to administer increasingly larger doses to maintain the same effect. 

This may happen with MXE if it used in an extended and repetitive manner. In this case, it takes approximately 1-2 weeks for the tolerance to return to normal without continued use. In addition, being an NMDA receptor antagonist, MXE demonstrates cross-tolerance with other dissociatives. That is to say, after consuming MXE, other dissociatives will produce a reduced effect.

MXE vs Ketamine

MXE and ketamine are both NMDA antagonists and dissociative anesthetics of the arylcyclohexylamine class. Both compounds produce similar effects on cognition, producing rapid antidepressant effects, analgesia, euphoria, dissociation, and hallucinations. At high doses, MXE produces an “M-hole” that parallels a K-hole experience, characterized by a profound dissociation of mind from body.

Due to some modifications of ketamine’s chemical structure, MXE has a slower onset of action, longer duration, and a higher intensity of effects. Due to this increased potency, MXE has been advertised as a “bladder friendly” analog of ketamine, but clinical data hasn’t supported this claim.

According to trip reports, the MXE experience is similar to the ketamine experience, but some believe it is easier to recall and integrate after the trip.

6. Uses 


Starting in 2010, MXE began to be used recreationally for its dissociative and hallucinogenic effects. Recreationally, it is typically consumed orally or intranasally in home environments and nighttime party environments such as dances and raves. Around its inception, MXE’s recreational popularity expanded as a result of its higher accessibility and lower cost compared to ketamine. It was initially marketed as safer for the liver and kidneys than ketamine, but this was speculative and not clinically supported.

The recreational use of MXE grew largely among young adults as a legal high purchasable from head shops and research chemical vendors on the Internet. Once government bans began to take effect in the mid-2010s, MXE began to be seized and its appearance on the gray market largely disappeared.


Ketamine has been widely used as an analgesic in high doses for a variety of pain-related disorders. This suggests MXE possesses similar medical utility for pain management.

A 2016 case study documented a 29-year old man’s use of MXE to alleviate chronic foot pain associated with a foot surgery he had the year prior. The man used 5-10mg every four hours for 5 days to treat his foot pain prior to his admittance to the emergency department for MXE-related intoxication. 

Recent rodent studies have supported MXE’s pain-inhibiting effects. Researchers have found MXE produces analgesic effects in rats at 5 mg/kg and raises the pain threshold in mice better than ketamine. MXE may exert its analgesic effects by binding to NMDA receptors and µ-opioid receptors (the same receptors targeted by opioids like morphine). Additional research is needed to reveal how exactly it inhibits pain.


MXE possesses potent antidepressant properties due to its pharmacological and structural similarities to ketamine. According to many self-reports, MXE produces rapid depression relief and an antidepressant afterglow, similar to ketamine, which can last up to a week.

Rodent studies have found that MXE creates rapid and sustained antidepressant and anxiolytic (anxiety-reducing) effects at sub-anesthetic doses. The antidepressant effects were found to be mediated through serotonergic and glutamatergic mechanisms. Specifically, MXE was found to alter gene expression of serotonin and glutamate in the hippocampus, a region of the brain critically involved in learning and memory. 

MXE has also been reportedly used to treat post-traumatic stress disorder (PTSD). According to a 2017 case report, a US veteran suffering from PTSD used daily high doses of MXE (intranasal and intravenous) to produce calming effects and facilitate spiritual experiences. The authors note that the alleviation of PTSD symptoms likely arises from MXE’s blockade of the NMDA receptor, similar to ketamine’s antidepressant action, as well as its ability to increase Brain-Derived Neurotrophic Factor (BDNF). BDNF is a growth factor involved in learning, memory, and the extinction of fear memory. Studies have found that BDNF levels are significantly lower in individuals with PTSD.

Spiritually (Developmentally) 

At low doses in social settings, MXE may reduce negative moods and enhance empathy and sociability, leading to more authentic and meaningful conversation. In addition, MXE may heighten creativity and aesthetic appreciation, leading to a deeper interest or involvement with meditation, spirituality, film, and music. 

In solitary settings, MXE may enhance introspection, allowing users to go deeper inside and examine interpersonal issues and relationships from a novel vantage point. MXE’s ability to foster new perspectives on problems can promote the development of new coping strategies (such as deep acceptance) for fear, anxiety, and depression. Many individuals report MXE facilitates the vivid recall of emotionally-charged memories, which can bring about catharsis and healing.

At high doses, MXE can bring on profound spiritual and transcendent experiences, leading to the dissolution of normal space-time constraints. Similar to the classic psychedelics, these mystical experiences may bring on ego dissolution, where the boundaries between inner and outer dissolve. These profound experiences can lead to existential self-realization, inner personal growth, and newfound philosophical views on consciousness. 

7. MXE Today 

Trends in Use

According to several online surveys, MXE use peaked around 2011 and has since declined as global bans on MXE increasingly took effect.

An online survey conducted in 2011 by the Global Drug Survey (GDS) investigated the prevalence of MXE use within poly-drug users in the UK clubbing scene. Out of the 7,770 UK-based respondents, 326 (4.2%) reported past-year use of MXE, while 197 (2.6%) reported past-month use. The majority of the survey respondents were employed white men younger than 30 years of age.

A similar study by Lawn and colleagues sought to determine the prevalence of MXE use in the United States and the United Kingdom between 2011 and 2012. The researchers found MXE use significantly increased in the United States from 1.6% in 2011 (n=3830) to 5% in 2012 (n=3756) for past year use, while past-month use rose slightly from 1.6% in 2011 to 2.0% in 2012. During this same time period, MXE use significantly declined in the UK in parallel with legislative bans. Indeed, past-year use decreased from 4.2% in 2011 (n=8184) to 3.0% in 2012 (n=7360), while past-month use decreased from 2.4% in 2011 to 0.7% in 2012.

Current Studies and Research

As of this writing, only 108 studies relating to MXE are found on Pubmed. Most of the MXE literature is comprised of toxicology studies and individual case studies of MXE intoxication. Several preliminary animal studies have investigated MXE’s addictive, analgesic, dissociative, and antidepressant properties. No past or ongoing controlled clinical studies involving MXE exist in humans.

Drug Testing Info

MXE cannot be detected with standard urine drug tests. Only specialized toxicology screenings can detect MXE.

Around the World

While MXE was widely available at the start of the previous decade, it has now largely vanished from the online research chemical market after global bans outlawed its manufacturing, sale, use, and possession. Prior to its global bans, MXE was primarily synthesized in China. However, it is now listed as a Schedule I substance there and in numerous other countries (reference ‘Legality’ section)


What Does MXE Do?

MXE primarily acts as an NMDA receptor antagonist and serotonin reuptake inhibitor. These mechanisms of action result in MXE’s dissociative, anesthetic, hallucinogenic, and antidepressant effects. 

Is MXE Stronger than Ketamine?

Yes. The addition of the N-ethyl group to ketamine’s chemical structure is responsible for MXE’s increased potency and duration of action. Users should start with the lowest possible dose to gauge reactions, as the effects can differ widely from user to user.

How Long Does a MXE Trip Last?

The effects of MXE last from 2.5-4 hours when used intranasally, 3-5 hours when used orally, and 2-3 hours when used intramuscularly. Some users report effects lasting up to 24 hours, which is more likely to occur when redosed or used in high doses. All routes of administration have after-effects that may last between 2 to 48 hours. 

How Long Does MXE Stay in Your System?

MXE has an elimination half-life of 3-6 hours. Therefore, in 15-30 hours, 97% of an MXE dose is eliminated from the body. 

Is MXE Dangerous?

MXE can be dangerous when used excessively in high doses, in combination with other drugs, and under improper set and setting. Given that MXE is a recent research chemical, no controlled human trials have been conducted to evaluate its safety, especially in the long term. Animal studies suggest chronic, high doses of MXE may be neurotoxic and damage the urinary tract similar to ketamine. 

Is MXE Addictive?

There is no literature concerning the abuse liability of MXE in humans, however, self-reports indicate that MXE can lead to compulsive misuse and addictive behavior. Animal studies have demonstrated that MXE activates dopaminergic brain regions associated with addiction, and rats will self-administer MXE similar to common drugs of abuse.

Can You Die from MXE?

MXE deaths are unheard of when used by itself in common dose ranges and under proper set and setting. The more than 20 fatal overdoses associated with MXE were caused by hyperthermia (accidents from improper set and setting) or combinations with other drugs.

Disclaimer: Methoxetamine is a potentially categorised as an illegal drug. Reality Sandwich is not encouraging the use of this drug where it is prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore this substance.  This guide is intended to give educational content and should in no way be viewed as medical recommendations.

RS Contributing Author: Dylan Beard 

Dylan Beard is a freelance science writer and editor based in the beautiful Pacific Northwest. After finishing his physics degree and dabbling in neuroscience research at UC Santa Barbara in 2017, he returned to his first love: writing. As a long-term fan of the human brain, he loves exploring the latest research on psychedelics, nootropics, psychology, consciousness, meditation, and more. When not writing, you can probably find him on hiking trails around Oregon and Washington or listening to podcasts. Feel free to follow him on Insta @dylancb88.

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Differentiating DMT and Near-Death Experiences
Some say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out.

DMT Research from 1956 to the Edge of Time
From a representative sample of a suitably psychedelic crowd, you’d be hard pressed to find someone who couldn’t tell you all about Albert Hofmann’s enchanted bicycle ride after swallowing what turned out to be a massive dose of LSD. Far fewer, however, could tell you much about the world’s first DMT trip.

The Ultimate Guide to DMT Pricing
Check out our ultimate guide on DMT pricing to learn what to expect when purchasing DMT for your first time.

DMT Milking | Reality Sandwich
Indigenous cultures have used 5-MeO-DMT for centuries. With the surge in demand for psychedelic toad milk, is DMT Milking harming the frogs?

Why Does DMT Pervade Nature?
With the presence of DMT in nature everywhere – including human brains – why does it continue to baffle science?

DMT Substance Guide: Effects, Common Uses, Safety
Our ultimate guide to DMT has everything you want to know about this powerful psychedelic referred to as “the spirit molecule”.

DMT for Depression: Paving the Way for New Medicine
We’ve been waiting for an effective depression treatment. Studies show DMT for depression works even for treatment resistant patients.

Beating Addiction with DMT
Psychedelics have been studied for their help overcoming addiction. Read how DMT is helping addicts beat their substance abuse issues.

DMT Extraction: Behind the Scientific Process
Take a look at DMT extraction and the scientific process involved. Learn all you need to know including procedures and safety.

Microdosing DMT & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing DMT.

DMT Art: A Look Behind Visionary Creations
An entire genre of artwork is inspired by psychedelic trips with DMT. Read to learn about the entities and visions behind DMT art.

Changa vs. DMT: What You Need to Know
While similar (changa contains DMT), each drug has its own unique effect and feeling. Let’s compare and contrast changa vs DMT.

5-MeO-DMT Guide: Effects, Benefits, Safety, and Legality
5-Meo-DMT comes from the Sonora Desert toad. Here is everything you want to know about 5-Meo-DMT and how it compares to 4-AcO-DMT.

4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality
This guide tells you everything about 4 AcO DMT & 5 MeO DMT, that belong to the tryptamine class, and are similar but slightly different to DMT.

LSD Guides (lysergic acid diethylamide)

How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

Ayahuasca Guides

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.


Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.


The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.


Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.


Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.


The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.


Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.


Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.


Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.


Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.


Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.


Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.


Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?


Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.


Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.


Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

Ketamine Guides

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

MDMA / Ecstasy Guides

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

Cocaine Guides

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

Cannabis Guides

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

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