1P LSD: Effects, Benefits, Safety Explained

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1P LSD first debuted online as a research chemical in 2015. It has been sold as a designer psychedelic drug ever since. Little is known about its invention as academic literature about the substance does not exist prior to its debut online. Due to the lack of analytical, chemical, and pharmacological data on 1P LSD, conclusive scientific evidence is lacking on its properties, behavior, and risks. However, it is assumed that 1P LSD functions similarly to LSD. According to user accounts, its subjective effects are almost identical. 

1P LSD is considered an analogue to LSD.  An analogue is a substance that is structurally and functionally similar to the original substance. It was created by modifying the molecular structure of LSD, probably in an attempt to produce a novel derivative of LSD that would technically fall into a legal loophole in many countries. 1P LSD is also a homologue of ALD-52, which means that a molecular chain was added to its parent molecule.

The United States does not control 1P LSD on the federal level. However, it could be considered an analogue, which would make it illegal under the Federal Analogue Act.

What You Will Learn About 1P LSD

  • 1P LSD is a psychedelic substance of the lysergamide class and is considered an analogue of LSD and homologue of ALD-52. It also could be a “prodrug” of LSD. 
  • The legality of 1P LSD varies from country to country. However, it is illegal in 13 countries.
  • Because it is so closely related to LSD, it is considered relatively safe to use. However, there are increased risks if you have a pre-existing medical condition, heart condition, or are on certain kinds of medications.
  • 1P LSD first appeared online in 2015 as a designer drug. We don’t know who first created it, although some speculate that it was Alexander Shulgin.

What is 1P LSD? 

1P LSD is short for 1-propionyl-lysergic acid diethylamide. As an analogue of LSD and homologue of ALD-52, it is classified as a psychedelic substance of the lysergamide class. 1P LSD is made by adding a propionyl group to the nitrogen molecule of LSD’s indole. In other words, it is the same substance as LSD with an additional chemical chain. Recently, it has become available as a research chemical in the form of blotters and powdered material. Typically, it takes 45-90 minutes to begin to feel the effects and lasts anywhere between 8-12 hours. 

Pharmacology

Though 1P LSD functions similarly to LSD, too little research exists to make definitive claims. However, due to its chemical similarities, it functions as a serotonergic substance. It binds to the 5-HT serotonin receptors in the brain or body. The way LSD binds to the 5-HT2A receptor, in particular, causes a cross-activation of the 5-HT2A receptor heteromer. In other words, this relationship produces long-lasting psychedelic effects. 1P-LSD probably binds with the monoamine receptors responsible for dopamine and norepinephrine but, again, little data exists to back up these claims.  

A study from 2015 indicated that 1P-LSD shows 38% the potency of LSD in mice, though the drug did exhibit LSD-like behavior. There is a theory that 1P-LSD may act as a prodrug for LSD, which would mean that it turns into LSD once metabolized in the body. However, more studies need to be conducted in order to determine how 1P-LSD functions and if it is capable of producing its own psychedelic effects.

1P LSD vs LSD: What’s the Difference?

Subjectively speaking, users claim that the effects are more or less identical. However, a recent study investigated the similarities and differences in mice. Researchers found that 1P LSD shows 38% of the potency of LSD. This could indicate that 1P LSD is a prodrug, which means that it metabolizes into LSD in the body. The process could make 1P LSD weaker in comparison as well as slower to take effect. According to users, however, this does not seem to accurately reflect their experiences. 

The main differences include:

  • Molecular weight: LSD, 320g/mol | 1P LSD, 380g/mol.
  • 1P LSD: has three more carbons and one more oxygen in its molecular structure than LSD has. 
  • Legalities: LSD is an illegal drug in most countries. 1P LSD is a research chemical and is legal.
  • Effects: 1P LSD may be more stimulating and fast-paced in regard to its physical and cognitive effects. However, overall, the average user expresses that they cannot tell the difference.

Overall, more scientific research needs to be done in order to determine how they compare to and differ from one another.

1P-LSD Experience

As mentioned earlier, the 1P-LSD experience is commonly reported to be virtually indistinguishable from LSD-25. 

However, some people report a stronger body load and sense of time dilation than what they’ve experienced on LSD-25. Some psychonauts state 1P-LSD is less of a visual trip than LSD-25, while others couldn’t tell the difference in terms of visual effects. Many 1P-LSD reports circle around color enhancement progressing to tracers, visual drifting, and geometric open and closed eye visuals. 

The 1P-LSD experience is also known for its clean and open headspace, perhaps more reproducibly so than LSD-25 due to its dosing accuracy and purity. Fits of euphoric laughter, increased appreciation of music, emotional enhancement, and spiritual experiences that give way to enduring insights about the nature of reality are all commonly found in a 1P-LSD trip.

One user described his experience taking two blotter tabs of 1P-LSD in his Erowid trip report titled Lysergic’s Identical Twin:

“The things I had heard prior to this were that it was indistinguishable from LSD, and for the most part, I would have to agree. Maybe it might be slightly less visual, as I got slightly less color-shifting from it, but I could not honestly say if that was the case. There is a minor body load, but nothing too much – it’s just tingly at one point, and that could have been from other factors.

The other distinguishing factor for me was that time dilation was stronger on this compound than LSD. Time dilation started sooner (at about 20 minutes in). It was hard to keep track of time, but easy to keep track of the sun. Often I would find myself thinking 20 or 30 minutes had gone by when only 10 had.

It felt natural in the same way LSD does. It does the exact same things that LSD does. In every respect, it is LSD. Music enhancement, duration, visual effects, the way the body feels relaxed…it all was exactly like LSD. Had I been given this and told it was LSD, I would have believed the person, because how could I tell the difference other than that tingling sensation at one very specific point which may not even be totally attributed to this compound.”

Physical Effects

As research is scarce, information about the effects of 1P-LSD comes from subjective experiences. Users purport that its effects are identical to LSD and the two drugs cannot be told apart. Generally, 1P-LSD is featured as an energetic, stimulating drug that feels fast-paced but not forced. The effects may vary from person to person but according to users’ accounts they include:

  • A euphoric body high that is more intense compared to its visual or cognitive effects.
  • Tingling sensations at specific locations on the body.
  • Dilated pupils.
  • An increase in stamina.
  • Tactile enhancement.
  • Occasional nausea when consumed in moderate or high doses.
  • Appetite suppression.
  • Auditory enhancement.
  • Hallucinations such as color enhancement, geometry, and distortions characterized as cartoon-like in appearance.
  • Feelings of unity and interconnectedness.

Cognitive Effects 

  • Enhanced analytical/creative/conceptual thinking. 
  • Personal bias suppression.
  • Anxiety and Paranoia (not common in low or moderate doses and unusual. unless factors like set and setting are triggering).
  • Increase in focus (characteristically it feels less “forced” than other psychedelics). 
  • Cognitive euphoria.
  • Fits of laughter (normally as it is taking effect).
  • Dissolution of ego.
  • Time distortion.

Dosage

Common / Standard Dose

A common dose range for 1P-LSD is 50-125 mcg by oral administration (blotter tabs). Typically, vendors sell tabs that are dosed at 100mcg per tab. While a good starting point, the right dose for you can vary depending on several factors, including individual variability and tolerance levels, which can build rapidly. Strong doses generally range from 125-300 mcg, while heavy doses are above 300 mcg. 

Microdose 

Microdosing 1P-LSD involves ingesting a sub-perceptual dose by cutting the tab or volumetrically dosing. 1P-LSD is microdosed for the same reasons and in much the same way as its better known chemical cousin. This includes, but is not limited to, improving mood, productivity, well-being, creativity, and more. A common starting microdose for 1P-LSD is 15 mcg, the approximate threshold dose. This can then be titrated up depending on individual sensitivity and needs. Since 1P-LSD has been found to be 38% of the potency of LSD, those who microdose may require slightly more than the doses they are used to when microdosing LSD-25.

Similar to LSD-25, 1P-LSD is commonly microdosed every third day for a few months at a time. This schedule helps prevent the buildup of tolerance, which can dramatically reduce the benefits of microdosing. Users generally dose in the morning because of 1P-LSD’s long duration of action, which can lead to trouble sleeping if dosed late in the day.

Overdose 

Since 1P-LSD is just over five years old, there is very little data on its overdose potential and no known toxic dose. Being a prodrug, it is thought to have similar toxicity and potential for overdose as LSD-25. LSD-25 has a lethal dose of roughly 10,000 mcg extrapolated from rodent LD-50 studies. Like other serotonergic psychedelics, very high doses of 1P-LSD are associated with an increased risk of adverse psychological effects. This includes delusions, paranoia, anxiety, panic attacks, and psychotic features. 

Benefits & Risks

Concerning the risks and benefits of 1P LSD, know how much you’re taking and what kind of experience you are looking for. If you’re new to psychedelics, doing it alone might not be advisable. An unfavorable set and setting could potentiate a series of issues. 

If you’re taking medications or have a pre-existing condition, particularly those defined as cardiovascular or mental, then consult a trained physician or expert before taking any substance. There is a risk of vasoconstriction in the heart, and psychosis for bipolar disorder and schizophrenia. Furthermore, mixing certain pharmaceutical drugs may counter-interact with 1P LSD as well. Benzodiazepine tends to lower the effectiveness of lysergic acid diethylamide and any other psychedelic substance. Mixing certain antidepressants with LSD can result in serotonin syndrome due to an overload of serotonin in the central nervous system. 

Other concerns include HPPD and PTSD. HPPD, or hallucinogen persisting perception disorder, is a disorder where users see “visual snow” long after the trip has ended. This can disrupt an individual’s ability to perform regular tasks due to the distraction caused by visual snow. In more extreme cases HPPD can result in severe hallucinations for prolonged periods of time.

All these factors indicate the need for preparation and forethought to reduce the risks of taking 1P LSD.

Aside from that, the risks of 1P LSD are technically unknown. Since science governs the area of medicine, when we speak about a substance we cannot make definite claims about them unless backed up by science. Personal accounts, even if there are thousands, cannot technically be credited as factual.  However, 1P LSD appears to function like LSD, which would make it a relatively low-risk drug since scientific evidence on LSD shows that there are minimal adverse effects.

Top Reported Benefits

Recently, a resurged interest in LSD has led scientists to reconsider the studies that were conducted in the 50s and 60s. Those investigations primarily focused on treating depression, post-traumatic stress disorder, drug dependency, and reducing anxiety in end-of-life patients. Since the effects are similar to LSD, it might be able to address these issues and their associated symptoms.

The top reported benefits include:

  • Dissolution of the ego.
  • A decrease in anxiety and depression.
  • Euphoria.
  • Spiritual enhancement and feelings of unity.

Common Risks or Side Effects

Common risk and side effects could include:

  • Increased bodily temperature.
  • Appetite suppression.
  • Dehydration.
  • Increased blood pressure/heart-rate/perspiration.
  • Visuals such as enhanced colors/geometric patterns/cartoon-like imagery.
  • Time distortion.
  • Increased stamina.

1P LSD is available as a research chemical but is illegal in thirteen countries: Denmark, Finland, Germany, Estonia, Japan, Latvia, Lithuania, Norway, Sweden (listed as health hazard), and Switzerland. Romania classifies 1P LSD, but it is not technically illegal. In the United Kingdom, 1P-LSD may be illegal under the Psychoactive Substances Act. In the United States, 1P LSD is not controlled at the federal level. However, it could be considered an analogue to LSD in which case it would be illegal under the Federal Analogue Act.

FAQ

How long does 1P LSD Trip last?

The trip can last anywhere between 8-12 hours. 

When was 1P LSD Synthesized?

Good question. That remains unknown, but we do know that it appeared online as a designer drug in 2015.

Can You Buy 1P LSD?

If 1P-LSD is legal in your country or state, accurately-dosed blotters can be purchased relatively easily online. Keep in mind legal vendors are prohibited from saying they are selling 1P-LSD for human consumption. For this reason, it is labeled and sold for research purposes only. Online forums, such as the 1P-LSD subreddit, frequently discuss the most reliable current vendors.

1P LSD Safe?

Generally, lysergamides are known for their high safety profile. But since there have been no clinical research studies on 1P-LSD with humans, the drug’s long-term effects are unknown. However, 1P-LSD is believed to be metabolized into LSD-25 in the body, making its subjective effects and mechanism of action nearly indistinguishable. Like any other psychedelic, 1P-LSD is not physically addictive, and toxic doses are extremely high. The biggest safety risks are adverse psychological effects (such as precipitating psychosis or HPPD), as well as potential complications from vasoconstriction. 

What is the High Like on 1P LSD?

The high on 1P LSD is similar to LSD. It is a serotonergic substance, which means it’s a stimulating high that enhances feelings of euphoria and your experience of the environment. Not everyone has visuals but they tend to be a common experience. 

How Long Does it Take for 1P LSD to Kick In?

It usually takes around 45-90 minutes to begin to feel the effects. 

Does 1P LSD Show Up on a Drug Test?

1P LSD will only show up in an LSD drug test. LSD only shows up a maximum of 48 hours after ingestion in urine, not in hair.

Do You Have Real 1P LSD?

It is always a good idea to test your substances! If you use an Ehrlich’s reagent test, it’ll turn purple. On a marquis reagent test, it varies. Some results say dark green. Erowid would indicate that it’s real with the response: “no reaction.”

Does 1P LSD have a Comedown?

The comedown is between 2-4 hours with after effects lasting about two hours. However, the comedown can last up to 24 hours.

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Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?

 

Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.

 

Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.

 

Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

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