MDMA & Ecstasy Guide: Effects, Common Uses, Safety

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MDMA, also known as ecstasy and/or molly, is a popular recreational drug due to its euphoric and stimulating effects. First synthesized in 1927, MDMA remained relatively unknown to the public until the late sixties. In the 1970s, researchers began to discover its therapeutic potential, which showed particular success in marriage counseling. In the 1980s, it gained more prominent attention with the rise of its use in the rave scene. The government then scheduled MDMA as a Schedule I drug in 1985, and it has remained illegal ever since. However, that might soon be changing as more evidence attests to its therapeutic value in treating a variety of mental health conditions. Currently MDMA is in phase III clinical trials for FDA approval as a psychedelic therapy for PTSD.

What You Will Learn About MDMA

  • MDMA is an abbreviation for the substance 3,4-methylenedioxymethamphetamine.
  • It is a popular substance due to its psychedelic, stimulating, and empathogenic effects.
  • MDMA operates as a presynaptic releasing agent of serotonin, norepinephrine, and dopamine, which causes its effects.
  • Ann Shulgin brought MDMA to the field of psychedelic psychotherapy in the 1970s.
  • FDA banned MDMA in 1985.
  • Currently, phase III clinical trials are studying the effectiveness of using MDMA to help treat PTSD alongside regular therapy.
  • MDMA overdoses are extremely uncommon but has happened. One of the more recent overdoses occurred from an individual taking 2.3 grams at once. This is about 20 times a normal dose.


As a derivative of amphetamine, MDMA has stimulating and empathic effects that generally last about three to six hours. Currently, it is undergoing Phase III clinical trials to determine its effectiveness in treating post-traumatic stress disorder during psychedelic-assisted psychotherapy sessions. These clinical trials are putting pressure on the United States government to reclassify the substance for therapeutic use.

In 2014, it was the fifth most commonly used drug worldwide and the fourth most commonly used in the United Kingdom according to the Global Drug Survey.

What is MDMA

MDMA is a popular drug that acts as both a psychedelic and a stimulant. It is a derivative of amphetamine, and a member of the phenethylamine family which includes substances such as mescaline, 2C-B, speed, and methamphetamine. It induces the release of serotonin, norepinephrine, and dopamine from the presynaptic neuron into the synapse. This causes the user to experience energizing effects, euphoria, empathy, reduced inhibitions, feelings of connection to others, and enhanced sensation and perception.

After ingestion, concentration of MDMA in the blood stream begins to rise after about 30 minutes and reaches its maximum concentration after 1.5-3 hours. MDMA’s half-life is 6-7 hours. These time frames cause the effects to start about 30 minutes after ingestion, the peak of the effects to occur around 2 to 3 hours after ingestion, and the effects lasting a total of 3-5 hours.

Street Name

  • Ecstasy or E
  • Stacy
  • XTC or X
  • Malcolm X
  • Rolls
  • Beans
  • Adam
  • Molly (short for “molecular”) 
  • Mandy (more popular name in the UK) 
  • Mollie
  • The Love Drug
  • Happy pill

Scientific Name

MDMA Molecule

MDMA stands for 3,4-methylenedioxymethamphetamine, a derivative of amphetamine, which is why it produces some stimulant effects. It is a member of the larger group of ring-substituted phenethylamines. Phenethylamines without ring substitution usually behave solely as stimulants. However, the ring substitution in MDMA causes additional psychoactive effects, yet it is still less hallucinogenic than it’s homolog, methylenedioxyamphetamine (commonly known as MDA). 

A Synthetic Substance

As a synthetically made substance, MDMA is fabricated from scratch. The four most common precursors used to manufacture it are safrole, isosafrole, piperonal, and 3,4-methylenedioxyphenyl-2-propanone (PMK). One of these precursors is typically synthesized into MDP2P, or 3,4-methylenedioxyphenyl-2-propanone, then through reductive amination synthesized into MDMA. MDP2P can be synthesized by the isomerization of safrole within a strong base to create isosafrole then isosafrole is oxidized to create MDP2P. It can also be produced using the Wacker process which oxidizes safrole directly to MDP2P in the presence of a palladium catalyst.

Forms & Ways of Consumption

MDMA comes in tablet, powder, or crystal form. Molly refers to the powder form (usually comes in capsules). Whereas ecstasy is the tablet form. Most users consume it orally; although some occasionally consume it intranasally. MDMA is measured in milligrams. A standard dose is between 1.15-2.35mg/kg, although lower doses have been used in therapy. 100 milligrams is commonly the starting dose.

  • Ecstasy tablets: small round tablets that range in color, and often have a small icon pressed into them (such as a happy face, a heart, a number, or logo). 
  • MDMA powder: a white or off-white powder made out of MDMA crystals.
  • MDMA crystals: blackish/white crystal, which easily breaks off into powder.
  • Molly Water: dissolving MDMA powder into a beverage.


Most commonly, MDMA comes as an ecstasy tablet. Most high quality ecstasy tablets contain somewhere in the range of 80-150mg of the drug itself. However, pure MDMA powder must be mixed with other ingredients, such as lactose, to bind the powder together in order to make a tablet. MDMA could be cut with other potentially dangerous substances, so it is important to test its purity before use. (See Safety). The onset of effects from tablets takes anywhere from 20 to 60 minutes. These feelings typically last for 3 to 5 hours.


Snorting MDMA powder can cause effects to come on faster, typically around 15 minutes depending on the dosage and the individual’s metabolism, and may cause a shorter, but more intense peak. It reaches the brain faster because the nasal membrane allows the bloodstream to absorb the drug quicker. This method also allows some the drug to bypass being broken down by the liver. Because snorting causes the effects to come on faster and more intense, the risks associated with the drug increase. The user could experience extreme damage and/or irritation to their nasal cavity, as snorting any powder can cause lasting effects.


In 1912, Anton Kollisch first synthesized MDMA with Merck Pharmaceuticals in Germany while investigating hemostatic substances, agents that stop abnormal bleeding. Two years later, Merck Pharmaceuticals patented MDMA. In 1927, a chemist from Merck named Max Oberlin performed the first animal testing with the drug while investigating substances similar to adrenaline or ephedrine.

It wasn’t until the 70s however that scientists discovered its therapeutic potential in psychotherapy. It was particularly productive in helping with marriage counseling. The drug quickly became popular for recreational use because of its euphoric/empathetic effects on the user. Much like other psychedelics, after a rushed introduction to the public, the government quickly made it illegal and placed it on the Schedule I list in 1985.

Modern Day Development

In 1953, the Army Chemical Center tested MDMA toxicity on guinea pigs, dogs, mice, and rats as part of the MK-Ultra project. MK-Ultra was a set of experiments, most would consider unethical, performed by the CIA investigating hypnosis, neurosurgery, electroshock, torture, sexual blackmail, stage magic, and poison. These experiments did not stop until 1964. Eventually the New York Times exposed the truth in 1974 leading the Senate to call for an immediate inquiry into the U.S. Intelligence’s abuse of power.

These inquiries provoked President Ford to issue Executive Order 11905 putting an end to human testing without consent. The tests conducted on MDMA were able to determine that the drug was “less toxic” than MDA. MDA’s similarity to MDMA causes many to confuse the two. It is one of the most common substitutes and many times sold as MDMA. However, it generally causes stronger hallucinations and neurotoxicity.

Important Events, Findings, Studies

Recreational use of MDMA did not begin until the late 1960s, and law enforcement agencies did not know about it until The Bureau of Narcotics and Dangerous Drugs published their first encounter of the drug in 1970. It appears that MDMA became popular for recreational use as a legal replacement for MDA, which was highly sought after, and made illegal in 1970 by the Controlled Substances Act. The recreational use of MDMA quickly spread throughout the United States in the early 1980s, which led to its ban in 1985.

Alexander Shulgin

Alexander Shulgin was an American chemist and pharmacologist who became well-known in the psychedelic community. Because of his wife, Ann Shulgin, MDMA became extremely popular in the psychedelic psychotherapy community. It began to show measurably positive effects in psychotherapy particularly in treatments for Post-Traumatic Stress Disorder. During this period, MDMA gained its nickname “Adam,” because many therapists felt that it brought their patients into an innocent-like state and helped them communicate more willingly.

Alexander Shulgin famously created the Shulgin Rating Scale which provided a method for ranking the visual, auditory, and physical sensations of psychoactive substances and is still in use today. The scale uses simple pluses and minuses to detail the strength of the effects of a substance.

In September of 1976, Shulgin reported taking 16mg of MDMA and increasing doses until he reached 81mg on September 27th. He later reported the effects in his lab book as “amphetamine-like.”In 1991, Alexander and his wife Ann Shulgin published PIHKAL, which documented over 250 phenethylamines, including MDMA, mescaline, and 2C-B.

Michael Clegg

Michael Clegg was a catholic priest who got into MDMA during his student years. Clegg was one of the main pioneers responsible popularizing MDMA in the late ’70s and early ’80s — right up it’s ban in the mid ’80’s. He was also selling the substance and making a profit. Clegg came up with the name “ecstasy” because his own experience with this substance, as he stated, was similar to the experience of “ecstasy” described in the bible. There’s currently a television series in production about his life. 

Dr. Charles Grob

In 1992, FDA reviewed a MAPS supported protocol from Dr. Charles Grob for a study of MDMA and it’s potential to treat pain, anxiety, and depression in cancer patients. The FDA approved the study in 1992 as a phase I safety study, which ended in 1995. The study showed no unusual risks, which indicated that it could be safely administered within a clinical research context. Afterwards, Dr. Charles Grob requested permission to further study the substance with cancer patients, but was denied by the FDA twice.

Between the years of 1994 to 1999, 27 related ecstasy deaths occurred in the United States reported by SAMSA. Ecstasy tablets became notoriously impure and laced with other harmful substances such as amphetamines, bath salts (cathinones), methamphetamine, MDA, PMA, and PMMA.

Rick Doblin

Rick Doblin is the founder of the Multidisciplinary Association for Psychedelic Studies, or MAPS. Previously, he had owned and operated a construction company that relocated houses from 1975 to 1982. He then received a degree in psychology from the New College of Florida in 1987 and a doctorate in public policy from Harvard University in 2001. He co-founded MAPS in 1986 with the objective of getting the FDA to approve MDMA. After many years of work, it looks like Rick Doblin might finally achieve his goal. MDMA is currently at the final stage for FDA approval as a legal treatment for PTSD.

Laws and Legal Status

Is MDMA Illegal in the US?

MDMA is a Schedule I substance under the Controlled Substances Act. This makes MDMA illegal to manufacture, buy, possess, and distribute without a license from the DEA. By categorizing it as a Schedule I substance, the DEA believes that it meets the following three criteria: having a high potential for abuse, no legitimate medical use in treatment, and a lack of accepted safety laws for its use under medical supervision. The FDA has approved research for MDMA to explore whether it treats depression, PTSD, and psychological or emotional damage. The Phase III trials are expected to be complete by 2022, meaning MDMA-assisted psychotherapy may be a legal medical option by 2023.

When was MDMA made Illegal?

It became a Schedule I substance under the Controlled Substances Act in 1985 after an emergency classification by the DEA.

Where is MDMA Legal Internationally?

It is illegal to buy, sell, or produce MDMA in most countries. However, it is more of a “gray area” in certain countries. In Peru, it is legal to possess up to 250mg, as long as it’s the only drug on you. 


Mechanism of Action

The gastrointestinal tract absorbs MDMA. Then the liver metabolizes into an active metabolite called methoxyamphetamine. It is a serotonergic drug acting as a presynaptic releasing agent of serotonin, norepinephrine, and dopamine. The neurotransmitter serotonin (or 5-HT) is synthesized in 5-HT neurons and stored in synaptic vesicles. They then release 5-HT into the synaptic cleft in response to the activation of the 5-HT neurons. 5-HT is pumped back into the neuron through the reuptake pump where it is stored in the synaptic vesicles. When ingested, it blocks the reuptake of 5-HT.

Overall, MDMA affects 5-HT similarly to the way amphetamines affect dopamine (by inhibiting reuptake and causing the release of 5-HT). However, it has micromolar potency for the serotonin 5-HT2 (the psychedelic site), muscarinic M1, alpha-2 adrenergic (the cardiovascular site), and histamine H1 receptors. Many classic psychedelics (LSD, psilocybin, mescaline) seem to have agonist properties at the 5-HT2 receptor, so it is possible that the “psychedelic” effects occur because of the activity at this receptor. Some of the cardiovascular effects (increased heart rate, etc.) may be due to MDMA’s activity at the alpha-2adrenergic receptor.


Before we can discuss whether or not MDMA is toxic, we first need to define what makes a substance toxic. Toxicity is defined based on the levels of exposure required for a substance to cause harm to a human or animal. The level of toxicity is measured based on the dose required to cause harm to a human. Even water can be toxic in too high of a dose and lethal snake venom can be non-toxic in a small enough dose. LD50 is a common measurement of toxicity, which measures the lethal dose for half of the tested organisms.

MDMA Toxicity

When the government first started performing animal tests with MDMA in the 70s, they gave exorbitant amounts of the drug to animals and deemed it neurotoxic. Since then, extensive evidence proves that this is not the case. Considering the large amount of users internationally, serious acute adverse effects seem to be rare. The main thing to look out for is the danger of becoming dehydrated (especially because it is so popular in the rave scene). Additionally beware increased heart rate (especially if you have pre-existing heart conditions).

Between the years of 1977 and 1981, only eight individuals had to seek emergency room treatment after using the drug recreationally (according to the Drug Abuse Warning Network).


Like most other drugs, “neurotoxicity” is dose-dependent. One important thing about MDMA neurotoxicity however is its relationship with SSRIs. SSRIs inhibit the reuptake of serotonin causing serotonin to remain in the synaptic gap longer than it normally would which causes the presynaptic neuron to release less serotonin. Because of this, many researchers believe that SSRIs can reduce the ability of MDMA to cause neurotoxicity, but they also reduce MDMA’s ability to affect an individual. In conclusion, someone who regularly takes SSRIs may experience less neurotoxicity from MDMA, but will also not experience the normal effects of MDMA.

MDMA can and does produce adverse neurotoxic effects at some large and repeated doses. These adverse effects include decreases in concentration of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). These effects suggest that the drug causes either “down regulation,” meaning the neuron isn’t making nor retaining as many serotonergic markers, or the permanent loss of serotonergic axons.

However, we don’t know which of these effects MDMA causes in the brain. Factors like diet and lifestyle also affect serotonin levels. This “down regulation” may happen because MDMA rapidly inactivates the enzyme TPH and, thus, decreases serotonin levels until TPH activity returns to normal.

Long-Term Effects

Risks associated with possible long-term brain damage are more difficult to research. Government studies in animals show that MDMA can cause long-lasting decreases in the neurotransmitter serotonin. For these reasons, the “three-month rule” became a guideline amongst members in the community, to wait at least three months between each dose in order for their serotonin levels to become normal again. The true long-term effects however from exposure are still unknown.


MDMA and Alcohol

Mixing ecstasy with alcohol can be very dangerous, and cause severe dehydration. Furthermore, MDMA’s stimulant effects can hide alcohol’s sedating effects, causing an individual to drink more and become dangerously drunk. Basically, an individual could feel more sober than they actually are. A study done in 2002 found that the concentration of MDMA in each individual’s blood increased 13% after they drank alcohol. Research on rodents also suggests that mixing alcohol and MDMA may negatively affect the heart by placing unnecessary stress on it.


MDMA and MAOIs do not mix! If you are not sure if you are taking prescription MAOIs, you should know that Nardil, Parnate, Marplan, Eldepryl, and Aurorix/Manerix fall under this category. Ayahuasca brew also contains MAOIs in the form of harmine and harmaline. 

Mixing MDMA and MAOIs can cause a potentially fatal condition called “serotonin syndrome”. A number of people have died from the result of taking MDMA and MAOIs.

Other Drug Interactions

MDMA taken with other drugs that metabolize through the same liver enzyme known as CYP2D6, can interact dangerously. CYP2D6 also metabolizes Ritonavir (also mentioned below). Other drugs metabolized by CYP2D6 include codeine, opiate derivatives, and DXM. DXM is commonly found in impure ecstasy tablets. Also note that CYP2D6 also metabolizes Prozac. If you combine MDMA with any of these substances or any other drug metabolized by CYP2D6, both drugs will take longer to metabolize. In turn, the user will feel like they took a higher dose of each drug.

Never take MDMA with a protease inhibitor, a class of antiviral drugs. If you are using the protease inhibitor Ritonavir, do not take MDMA. This combination could be life-threatening.

Avoid other stimulants (prescription or recreational) when taking Ecstasy. Common stimulants include adderall, anabolic steroids, cocaine, Concerta, crack, Dexedrine, methamphetamine, and Ritalin. This can cause increased heart rate, blood pressure, and body temperature risks. A small number of MDMA users have reportedly experienced seizures after taking moderate doses of pure MDMA. While the cause remain unknown, it is thought to be from the acute systemic effects hyponatremia and hyperthermia. It is important to remain aware that MDMA can affect everyone differently.

For a more thorough list of interactions, consult the image below by Tripsit:

TripSit Guide to Drub Combinations Chart


  • A general rule of thumb in the community is: don’t take MDMA more than once every 3 months.
  • MDMA often gets cut with other stimulants that cause harmful interactions. This makes it particularly important to test MDMA for purity. It is generally recommended to use a Marquis test, Simon test, and Froehde test to ensure the purity of your MDMA. 

Besides the above mentioned interactions, there are two main things to be cautious of when taking MDMA. The first is remaining hydrated, and the second is purity. Because of the drug could accelerate one’s heart rate, users could become extremely dehydrated and overheated. Making it very important to stay hydrated during use.

It is very rare to find completely pure MDMA in the United States. Some use a series of harmful substances to cut MDMA in the black market making it extremely important to test any MDMA purchased for adulterants. Erowid runs an anonymous drug analysis program that catalogues common types of pills ecstasy comes in with their results. Even if you identify the pill you received on this database, it is still important to test as there are issues with counterfeit pills.

Can You Overdose on MDMA?

Finding the right MDMA dosage is important.

Consuming more than an appropriate dose of MDMA, can happen, but overdosing is extremely uncommon. One of the few cases of a pure MDMA overdose states that an individual took 2.3 grams of MDMA at once — almost twenty times a normal dose. According to the community, most overdoses occur because of consuming impure MDMA, or consuming a substance that isn’t even MDMA at all.

Common Side Effects

A psychedelic’s effects will have large variances, depending on the individual. A variety of factors contribute to what one will experience. For example, set and setting. Timothy Leary conducted a study with 175 individuals to whom he administered psilocybin in a setting similar to a common living room. In the larger groups of eight people or more the individuals felt less support from the group overall and had less pleasant experiences than those placed in smaller groups of six people or less. This is just one example but demonstrates how that can impact the experience and effects of a psychedelic experience.

Sometimes sensations will come on as the substance is taking effect as body is processing new information, and as the person goes through their experience. So it is important to remember that there is a range of effects possible. Every body is different. While everyone’s experience with MDMA will differ and the effects will shift throughout the experience, most users experience these common side effects:

  • Mood lift/euphoria
  • Increased willingness to communicate
  • Stimulation 
  • Decreased fear, anxiety, and insecurities
  • Feelings of love, passion, connection, and comfort
  • Decreased pain perception 
  • Feelings of love and empathy 
  • Increased awareness of the senses
  • Decreased appetite
  • Visual distortion 
  • Restlessness/nervousness
  • Jaw clenching 
  • Desire to move the mouth 
  • Unintended emotional bonding
  • Agitation 
  • Insomnia
  • Erectile dysfunction 
  • Increase in body temperature 
  • Nausea 
  • Sadness while/after coming down 
  • Post-trip crash or a post-trip afterglow, when the user experiences feelings of euphoria and clarity after tripping
  • Hangover causing depression and/or fatigue possible/controversial neurotoxicity 

MDMA and Psychological Conditions

Like all psychedelics, do not take MDMA if predisposed to any mental health conditions (especially schizophrenia and psychosis). MDMA can possibly exacerbate the symptoms of depression when used recreationally. However, current clinical trials indicate that MDMA can help drastically with conditions such as PTSD.

MDMA and Physical Conditions

Do not use MDMA if you have pre-existing heart conditions, a history of heart ailments, high blood pressure, glaucoma, liver/kidney disorders, or hypoglycemia.

Reality Sandwich MDMA DURATION Oral Chart

MDMA Today

Although MDMA remains a popular drug today for recreational use, the most astonishing developments occur within the research of MDMA-assisted psychotherapy.

Current Studies & Research

Within the current renaissance of psychedelic research, MDMA is showing among the most promising results in trails. Because of extraordinary results, the FDA has granted MAPS permission for phase three trials of MDMA-assisted psychotherapy for PTSD. This research involved a $26.9 million dollar plan to make MDMA an FDA-approved prescription medicine by 2021. MAPS, founded by Rick Doblin, is the only organization funding clinical trials of MDMA-assisted psychotherapy for PTSD, social anxiety in autistic adults, and anxiety associated with life-threatening illnesses.

Unlike commonly prescribed medications, psychiatrists only have to administer MDMA a few times during psychotherapy sessions to achieve long-lasting and positive results. MDMA is effective in treatment because it helps the individual feel more comfortable, safe, and communicative while remaining emotionally engaged through the processing of their trauma. Current drugs prescribed for a condition like PTSD only manage the symptoms. Whereas MDMA appears to aide the patient in dealing with the root of the problem. Therefore, MDMA is a possible permanent solution.

MDMAforPTSD.width 704


How long does MDMA stay in your system?

MDMA’s half-life is between six to seven hours. It is detectable in urine for 2-4 days after consumption due to the metabolites it produces.

How long does MDMA take to kick in?

When ingested orally, it takes about 30 minutes for the effects to begin. When taken intranasally, effects begin after about 15 minutes.

How long does MDMA last?

The effects last for 3-5 hours.

How is MDMA made?

It is made synthetically from one of four common precursors, safrole, isosafrole, piperonal, and 3,4-methylenedioxyphenyl-2-propanone (PMK). One of these precursors is typically synthesized into MDP2P, or 3,4-methylenedioxyphenyl-2-propanone, then through reductive amination synthesized into MDMA

What does MDMA do in my body?

As a presynaptic releasing agent, it induces the release of serotonin, norepinephrine, and dopamine from the presynaptic neuron into the synapse.

How to test MDMA?

As a recommendation, use a Marquis test, Simon test, and Froehde test to ensure the purity of your MDMA.

What does MDMA look like?

MDMA is typically a white powder or crystal, or pressed into a tablet. The powder can also be a tan color due to residual chemicals in a laboratory.

Where is MDMA legal?

In Peru, it is legal to possess up to 250mg, as long as it’s the only drug on you. Although possession is illegal in the Netherlands, authorities tend to overlook the possession of small amounts.

What is MDMA poisoning?

MDMA poisoning is an overdose which typically results in extreme hyponatremia, or cardiovascular arrest.

What is in MDMA?

MDMA is the chemical 3,4-Methyl​enedioxy​methamphetamine. In pill form, lactose is often used as a binding agent.

How does MDMA show up in my body?

MDMA is detectable 1-5 days after use. This time period depends on the amount taken, your metabolism, and other factors. If an individual has taken MDMA they will test positive for both amphetamines and methamphetamines. It will show up in a hair drug test for about 90 days.

Does MDMA degrade?

MDMA is a phenethylamine. In general, phenethylamines are quite stable molecules, and will stay stable for years or even decades. MAPS has a supply of MDMA for research manufactured by Dr. David Nichols and stored in Purdue University. In 1994, Dr. Nichols tested this supply eight years after originally synthesized,  and it showed no signs of deterioration.

What does MDMA taste like?

MDMA is extremely bitter, like any other alkaloid. 

What does MDMA smell Like?

MDMA has no distinct smell to humans.

Disclaimer: MDMA is potentially categorized as an illegal drug. Reality Sandwich is not encouraging the use of this drug where it is prohibited. However, we believe that providing information is imperative for the safety of those who choose to explore this substance. This guide is intended to give educational content and should in no way be viewed as medical recommendations.

If you have relevant information or updates concerning the research and studies of psychedelic substances, please reach out to We appreciate your contribution. –RS

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How to Ground After DMT
Knowing what to expect from a DMT comedown can help you integrate the experience to gain as much value as possible from your journey.

How To Get DMT
What kind of plants contain DMT? Are there other ways to access this psychedelic? Read on to learn more about how to get DMT.

How DMT is Made: Everything You Need to Know
Ever wonder how to make DMT? Read our guide to learn everything you need to know about the procedures of how DMT is made.

Having Sex on DMT: What You Need to Know
Have you ever wondered about sex on DMT? Learn how the God Molecule can influence your intimate experiences.

Does the Human Brain Make DMT? 
With scientific evidence showing us DMT in the brain, what can we conclude it is there for? Read on to learn more.

How to Use DMT Vape Pens
Read to learn all about DMT vape pens including: what to know when vaping, what to expect when purchasing a DMT cartridge, and vaping safely.

DMT Resources
This article is a comprehensive DMT resource providing extensive information from studies, books, documentaries, and more. Check it out!

Differentiating DMT and Near-Death Experiences
Some say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out.

DMT Research from 1956 to the Edge of Time
From a representative sample of a suitably psychedelic crowd, you’d be hard pressed to find someone who couldn’t tell you all about Albert Hofmann’s enchanted bicycle ride after swallowing what turned out to be a massive dose of LSD. Far fewer, however, could tell you much about the world’s first DMT trip.

The Ultimate Guide to DMT Pricing
Check out our ultimate guide on DMT pricing to learn what to expect when purchasing DMT for your first time.

DMT Milking | Reality Sandwich
Indigenous cultures have used 5-MeO-DMT for centuries. With the surge in demand for psychedelic toad milk, is DMT Milking harming the frogs?

Why Does DMT Pervade Nature?
With the presence of DMT in nature everywhere – including human brains – why does it continue to baffle science?

DMT Substance Guide: Effects, Common Uses, Safety
Our ultimate guide to DMT has everything you want to know about this powerful psychedelic referred to as “the spirit molecule”.

DMT for Depression: Paving the Way for New Medicine
We’ve been waiting for an effective depression treatment. Studies show DMT for depression works even for treatment resistant patients.

Beating Addiction with DMT
Psychedelics have been studied for their help overcoming addiction. Read how DMT is helping addicts beat their substance abuse issues.

DMT Extraction: Behind the Scientific Process
Take a look at DMT extraction and the scientific process involved. Learn all you need to know including procedures and safety.

Microdosing DMT & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing DMT.

DMT Art: A Look Behind Visionary Creations
An entire genre of artwork is inspired by psychedelic trips with DMT. Read to learn about the entities and visions behind DMT art.

Changa vs. DMT: What You Need to Know
While similar (changa contains DMT), each drug has its own unique effect and feeling. Let’s compare and contrast changa vs DMT.

5-MeO-DMT Guide: Effects, Benefits, Safety, and Legality
5-Meo-DMT comes from the Sonora Desert toad. Here is everything you want to know about 5-Meo-DMT and how it compares to 4-AcO-DMT.

4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality
This guide tells you everything about 4 AcO DMT & 5 MeO DMT, that belong to the tryptamine class, and are similar but slightly different to DMT.

How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.


Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.


The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.


Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.


Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.


The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.


Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.


Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.


Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.


Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.


Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.


Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.


Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?


Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.


Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.


Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

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