4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality

Jump to Section

Jump to Section

4-AcO-DMT (4-Acetoxy-N,N-dimethyltryptamine) is a semisynthetic tryptamine psychedelic that acts as a prodrug of psilocin, one of the main psychoactive compounds found in magic mushrooms. Since the compound metabolizes into psilocin in the body, similar to psilocybin, its effects closely resemble those of magic mushrooms. The Swiss chemist Albert Hofmann, as well as Franz Troxler at Sandoz Laboratories in Switzerland, first synthesized 4-AcO-DMT in 1963 . Its recreational use peaked in the 2010s following its arrival to the online research chemical market.

What is 4-AcO-DMT? 

4-AcO-DMT is a semisynthetic substance, meaning it is produced by synthesis with naturally occurring precursors. Other names for 4-AcO-DMT include psilacetin, 4-Acetoxy-DMT, and O-Acetylpsilocin.

4-AcO-DMT is encountered as an off-white or brown crystalline powder, either as its fumarate or hydrochloride salt. By far, the most common method of ingestion is oral, either by mixing the powder in solution or by taking tablets, capsules, or gel tabs. It can also be taken intranasally by insufflation, which produces a slightly shorter trip that comes on more rapidly.

The most common method of production is through acetylation of psilocin under alkaline or acidic conditions. Acetylation is a reaction that adds an acetyl functional group to a chemical compound. It produces effects similar or even identical to psilocybin’s, since they are both prodrugs of psilocin.

However, some users speculate that 4-AcO-DMT may produce its own psychoactive effects as well. Indeed, users that have injected or smoked it report near-immediate psychoactive effects. Both of these routes of administration bypass first-pass metabolism by the liver.

Pharmacology and Chemistry

The complete mechanism of action of 4-AcO-DMT is not completely understood at this time. However, scientists currently believe it acts as a prodrug of psilocin in the same way that psilocybin does. Dr. David Nichols even suggests it could be used as an alternative to psilocybin in pharmacological studies, given that it is a less challenging ester to synthesize.

Some users believe it has its own psychoactive properties as well. They report slightly differing effects between 4-AcO-DMT and psilocybin. Similar to other psychedelics, 4-AcO-DMT is an agonist of serotonin 5-HT2A receptors.

4-AcO-DMT’s chemical structure is similar to that of DMT with an attached acetoxy group on its indole ring. Similar to psilocybin (4-PO-DMT), 4-AcO-DMT is an ester of psilocin. While psilocybin is the O-phosphorylated form of psilocin, 4-AcO-DMT is the O-acetylated form. In its synthesis, psilocin is acetylated under either alkaline or acidic conditions. This makes it a semisynthetic compound since the precursor, psilocin, is a natural compound. Once ingested, 4-AcO-DMT is metabolized by the liver and deacetylated to psilocin. 

Common 4-AcO-DMT Dose

A common dose range for 4-AcO-DMT is 8–20 mg when orally ingested or insufflated. When insufflated, the effects come on more rapidly and don’t last as long. No matter the route of administration, aftereffects may be apparent for 12–14 hours following ingestion.

ThresholdLightCommonStrong
Oral2.5 mg3–7 mg8–20 mg20–35+ mg
Insufflation2-4 mg3–10 mg8–20 mg15–25+ mg
Source: Erowid.org

Physical Effects

One of the aspects of 4-AcO-DMT that draws so many users to it is its general lack of nausea in comparison to psilocybin mushrooms. While some users may still experience nausea after consuming 4-AcO-DMT, it is far less likely than with psilocybin mushrooms. Some users also report less of a body load than with psilocybin mushrooms. A body load is the feeling that your body is becoming heavier or more full and is generally uncomfortable. Other physical effects include:

  • Enhanced sensations
  • Pleasant tingling of the body
  • Sedation or stimulation
  • Sexual arousal
  • Dilated pupils
  • Motor impairment
  • Sweating
  • Chills
  • Flushing
  • Increased heart rate
  • Muscle fatigue
  • Nausea

Cognitive Effects 

The cognitive effects of 4-AcO-DMT are nearly identical to those of psilocybin mushrooms due to the way both compounds act as a prodrug of psilocin. With that said, many users report the 4-AcO-DMT trip has a warmer or more euphoric quality compared to psilocybin-containing mushrooms. These effects will vary based on dosage, the individual, and set and setting, but can include:

  • Brightened colors
  • Enhanced and altered visual perception
  • Introspection, spiritual and philosophical insights
  • Contact with autonomous entities
  • Inner peace
  • Induction of a dream-like state
  • Euphoria
  • Enhanced empathy
  • Altered sense of reality
  • Closed and open eye visuals
  • Auditory hallucinations
  • Altered thought patterns
  • Distorted sense of time
  • Loss of ego
  • Synesthesia
  • Anxiety and fear
  • Paranoia
  • Sleeplessness

Top Reported Benefits

Reported benefits of consuming 4-AcO-DMT are similar to those of most other psychedelics, particularly psilocybin mushrooms. 4-AcO-DMT may hold therapeutic potential for the treatment of depression, PTSD, anxiety, OCD, and addiction. Microdosing 4-AcO-DMT (1–2.5 mg regimented doses) may enhance sociability, improve mood, and increase creativity and focus.

One user reports that several 4-AcO-DMT trips and subsequent integration provided profound relief to his depression and OCD symptoms. His trips allowed him to process and heal childhood trauma, examine self-limiting beliefs, accept himself fully, and vent deeply repressed emotions. 

Another user reports 4-AcO-DMT helped with quitting cigarettes, and understanding the beneficial aspects of alone time after consistently being in long-term relationships.

With a 20 mg oral dose, one user reports a healing experience that allowed him to further accept and appreciate his own individuality. He also realized that he had too many possessions and was too involved with negative news. This led him to live a happier, more fulfilling life after the trip.

After an extremely high dose, one user also reports he felt the heavy trip helped him overcome a wide range of substance addictions.

Common Risks or Side Effects

With the limited history of use and research available on 4-AcO-DMT, a comprehensive set of risks cannot be determined at this time. Being a relatively recent research chemical, the long-term safety and toxicity of 4-AcO-DMT haven’t been studied in a clinical context.

Due to its chemical similarity to psilocybin and psilocin, however, it’s assumed to have a similar safety profile. Like psilocybin, 4-AcO-DMT is considered to be non-addictive and with low abuse potential. High doses (above 25 mg) have not been linked to fatalities. However, these doses have caused severe adverse effects such as blackouts, seizures, hypertension, and vomiting. 

Taking 4-AcO-DMT with lithium, tramadol, and stimulants such as amphetamines and cocaine may increase the chance of seizures or psychosis, so these combinations are strongly discouraged. In addition, 4-AcO-DMT’s effects may be strongly potentiated by MAOIs (monoamine oxidase inhibitors), MDMA, and cannabis. These combinations may increase the chance of negative psychological symptoms such as paranoia, panic attacks, anxiety, and psychosis.

The largest risk of taking any psychedelics includes the potential to develop HPPD, PTSD, or psychosis. HPPD, or hallucinogen persisting perception disorder, involves a user experiencing hallucinations well after a trip has ended. These hallucinations vary from minor to severe. Some individuals suffering from this disorder experience light visual snow while others experience full-blown hallucinations. A particularly difficult or negative trip can cause HPPD or PTSD. Psychosis particularly affects individuals with a history of schizophrenia or psychotic breaks. Most users never experience any of these disorders, but they can occur.

4-AcO-DMT Legality

In the United States, the Controlled Substances Act does not list 4-AcO-DMT as a controlled substance. However, its use, sale, and possession can be prosecuted as for a Schedule 1 substance under the Federal Analog Act if the purpose is for human consumption.

Australia lists 4-AcO-DMT as a Schedule 9 prohibited substance under the Poisons Standard as an analog of psilocin.

The United Kingdom lists it as a Class A drug under the Misuse of Drugs Act.

Italy and Sweden also list 4-AcO-DMT as a controlled substance.

4-aco-dmt-va-5-meo-dmt-comparison-chart

4-AcO-DMT vs 5-MeO-DMT: What’s the Difference?

Despite both 5-MeO-DMT and 4-AcO-DMT being derivatives of DMT, they act in very different ways within the body and produce vastly different effects. 4-AcO-DMT likely acts as a prodrug of psilocin, making it closer in effects to psilocybin than DMT or 5-MeO-DMT.

The most common way to make 5-AcO-DMT involves the semisynthesis of psilocin through acetylation under alkaline or acidic conditions. The effects of 4-AcO-DMT last up to six hours, whereas 5-MeO-DMT’s effects only last for up to an hour.

They also differ in the way they are consumed. 5-MeO-DMT does not activate when ingested orally without an MAOI (a potentially dangerous combination) and must be either insufflated or smoked. 4-AcO-DMT can be ingested orally or insufflated, but produces toxic compounds when smoked if not in a freebase form.

FAQ

How long does it take for 4-AcO-DMT to peak?

4-AcO-DMT is metabolized by the body more quickly than mushrooms that contain psilocybin. For this reason, the trip usually comes on more rapidly and intensely than with magic mushrooms. When orally ingested, the effects typically peak in 2 to 3 hours. When insufflated, the “come up” is more rapid, and the effects peak in 1 to 3 hours.

What is 4-AcO-DMT Fumarate?

4-AcO-DMT fumarate is one of the two salt forms of 4-AcO-DMT that contains two molecules of 4-AcO-DMT bound to one molecule of fumarate. 4-AcO-DMT is most commonly synthesized as the fumarate crystalline salt. Compared to the hydrochloride salt (4-AcO-DMT HCl), 4-AcO-DMT fumarate is more stable but slightly less potent. By weight, 4-AcO-DMT HCl is approximately 7% more potent than the fumarate salt.

RS Contributing Author: Dylan Beard 

Dylan Beard is a freelance science writer and editor based in the beautiful Pacific Northwest. After finishing his physics degree and dabbling in neuroscience research at UC Santa Barbara in 2017, he returned to his first love: writing. As a long-term fan of the human brain, he loves exploring the latest research on psychedelics, nootropics, psychology, consciousness, meditation, and more. When not writing, you can probably find him on hiking trails around Oregon and Washington or listening to podcasts. Feel free to follow him on Insta @dylancb88.

Psychedelic Resources

A Foraging Trip: Where Do Magic Mushrooms Grow?
Eager to learn more about the origin of psilocybin species? Read this article to find out where magic mushrooms grow and more!

How to Make Shroom Tea: Best Recipe and Dosage
A step by step guide on how to brew shroom tea, and why entheogenic psilocybin tea is a preferred method for psychedelic connoisseurs.

R. Gordon Wasson: Author and Mushroom Expert
Learn about R. Gordon Wasson, the “legendary mushroom expert” and popular figure within the psychonaut community.

Shrooms vs Acid: Differences and Similarities Explained
Ever wondered what the differences are between shrooms vs acid, or if you can take both together? This guide explains what you need to know.

Quantum Mechanics, Reality, and Magic Mushrooms
Scientist and author Dr. Chris Becker takes an in-depth approach in understanding how we perceive reality through magic mushrooms and quantum mechanics.

Psilocybin Guide: Effects, Common Uses, Safety
Our ultimate guide to Psilocybin has everything you want to know about this psychedelic fungi from its uses to its legal status.

The Psilocybin Experience: What’s the Deal With Magic Mushrooms?
From microdoses to macrodoses, the psilocybin experience has been sought after both medicinally and recreationally for millennia.

Psilocybin and Magic Mushroom Resources
Curious to learn more about psilocybin? This guide is a comprehensive psilocybin resource containing books, therapeutic studies, and more.

Paul Stamets Profile: Mushroom Guru, Filmmaker, Nutritionist, Scientist
Learn about Paul Stamets, read his thoughts on psilocybin mircodosing, the future of psilocybin, and his recent film “Fantastic Fungi”.

Microdosing Psilocybin & Common Dosage Explained
Microdosing, though imperceivably, is showing to have many health benefits–here is everything you want to know about microdosing psilocybin.

Psilocybin Nasal Spray: Relief for Anxiety, PTSD, and Depression
Microdosing nasal spray with psilocybin, is that possible?! Oregan a start-up Silo Wellness believes so and has created this new option for PTSD treatment.

Mazatec Mushroom Usage: Notes on Approach, Setting and Species for Curious Psilonauts
A look at traditional Mazatec psilocybin mushroom usage, and a comparison to the cliniical therapeutic approach, with an examination of the Mazatec setting and species used in veladas.

María Sabina: The Mazatec Magic Mushroom Woman
Magic mushrooms are incredibly popular today. How they became introduced to into American culture isn’t usually a topic discussed while tripping on psilocybin fungi. We all may have María Sabina to thank for exposing the Western world to the healing properties of the psilocybin mushroom.

Guide to Magic Mushroom Strains
Are there different types of psilocybin? Read our guide to learn about the different magic mushroom strains and their individual effects.

Kilindi Iyi: Mycologist, Traveler, Teacher
Learn about traveler and mycologist Kilindi Iyi known in the psychedelic community for his research and exploration of psilocybin.

How to Store Shrooms: Best Practices
How do you store shrooms for optimal shelf life? Learn how and why the proper storage method is so important.

Shroom Chocolate Recipes: How to Make Magic Mushroom Chocolates
This recipe provides step by step directions on how you can make mushroom chocolates with the necessary ingredients. Read to learn more!

Why Do People Use Psilocybin? New Johns Hopkins Study
Johns Hopkins University School of Medicines has just published a new study on psychoactive effects of psilocybin. Read here to learn more.

How-To Lemon Tek: Ultimate Guide and Recipe
This master guide will teach you how to lemon tek, preventing the onset of negative effects after consuming psilocybin. Read to learn more!

How to Intensify a Mushroom Trip
Learn about techniques like Lemon tekking, or discover the right time to consume cannabis if you are looking to intensify a mushroom trip.

How to Grow Magic Mushrooms: Step-by-Step
This step-by-step guide will show you how to grow magic mushrooms at home. Read this guide before trying it on your own.

How to Dry Magic Mushrooms: Best Practices
Read to learn more about specifics for the best practices on how to dry magic mushrooms after harvesting season.

How to Buy Psilocybin Spores
Interested in psilocybin mushrooms? We’ll walk you through all you need to know to obtain mushroom spores. Nosh on this delish How To guide.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

Having Sex on Shrooms: Good or Bad Idea?
Is having sex on shrooms a good idea or an accident waiting to happen? Find out in our guide to sex on magic mushrooms.

Gold Cap Shrooms Guide: Spores, Effects, Identification
Read this guide to learn more about the different characteristics of gold cap mushrooms, and how they differ from other psilocybin species.

Guide to Cooking with Magic Mushrooms
From cookies to smoothies and sandwiches, we cover various methods of cooking with magic mushrooms for the ultimate snack.

2020 Election: The Decriminalize Psilocybin Movement
Are you curious if mushrooms will follow in marijuana’s footsteps? Read to learn about how the U.S. is moving to decriminalize psilocybin.

Oregon’s Initiative to Legalize Mushrooms | Initiative Petition 34
Oregon continues to push ahead with their initiative to legalize Psilocybin in 2020. The measure received its official title and now needs signatures.

Canada Approves Psilocybin Treatment for Terminally-Ill Cancer Patients
Canada’s Minister of Health, Patty Hajdu approved the use of psilocybin to help ease anxiety and depression of four terminal cancer patients.

Mapping the DMT Experience
With only firsthand experiences to share, how can we fully map the DMT experience? Let’s explore what we know about this powerful psychedelic.

Guide to Machine Elves and Other DMT Entities
This guide discusses machine elves, clockwork elves, and other common DMT entities that people experience during a DMT trip.

Is the DMT Experience a Hallucination? 
What if the DMT realm was the real world, and our everyday lives were merely a game we had chosen to play?

How to Store DMT
Not sure how to store DMT? Read this piece to learn the best practices and elements of advice to keep your stuff fresh.

What Does 5-MeO-DMT Show Us About Consciousness?
How does our brain differentiate between what’s real and what’s not? Read to learn what can 5-MeO-DMT show us about consciousness.

How to Smoke DMT: Processes Explained
There are many ways to smoke DMT and we’ve outlined some of the best processes to consider before embarking on your journey.

How to Ground After DMT
Knowing what to expect from a DMT comedown can help you integrate the experience to gain as much value as possible from your journey.

How To Get DMT
What kind of plants contain DMT? Are there other ways to access this psychedelic? Read on to learn more about how to get DMT.

How DMT is Made: Everything You Need to Know
Ever wonder how to make DMT? Read our guide to learn everything you need to know about the procedures of how DMT is made.

Having Sex on DMT: What You Need to Know
Have you ever wondered about sex on DMT? Learn how the God Molecule can influence your intimate experiences.

Does the Human Brain Make DMT? 
With scientific evidence showing us DMT in the brain, what can we conclude it is there for? Read on to learn more.

How to Use DMT Vape Pens
Read to learn all about DMT vape pens including: what to know when vaping, what to expect when purchasing a DMT cartridge, and vaping safely.

DMT Resources
This article is a comprehensive DMT resource providing extensive information from studies, books, documentaries, and more. Check it out!

Differentiating DMT and Near-Death Experiences
Some say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out.

DMT Research from 1956 to the Edge of Time
From a representative sample of a suitably psychedelic crowd, you’d be hard pressed to find someone who couldn’t tell you all about Albert Hofmann’s enchanted bicycle ride after swallowing what turned out to be a massive dose of LSD. Far fewer, however, could tell you much about the world’s first DMT trip.

The Ultimate Guide to DMT Pricing
Check out our ultimate guide on DMT pricing to learn what to expect when purchasing DMT for your first time.

DMT Milking | Reality Sandwich
Indigenous cultures have used 5-MeO-DMT for centuries. With the surge in demand for psychedelic toad milk, is DMT Milking harming the frogs?

Why Does DMT Pervade Nature?
With the presence of DMT in nature everywhere – including human brains – why does it continue to baffle science?

DMT Substance Guide: Effects, Common Uses, Safety
Our ultimate guide to DMT has everything you want to know about this powerful psychedelic referred to as “the spirit molecule”.

DMT for Depression: Paving the Way for New Medicine
We’ve been waiting for an effective depression treatment. Studies show DMT for depression works even for treatment resistant patients.

Beating Addiction with DMT
Psychedelics have been studied for their help overcoming addiction. Read how DMT is helping addicts beat their substance abuse issues.

DMT Extraction: Behind the Scientific Process
Take a look at DMT extraction and the scientific process involved. Learn all you need to know including procedures and safety.

Microdosing DMT & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing DMT.

DMT Art: A Look Behind Visionary Creations
An entire genre of artwork is inspired by psychedelic trips with DMT. Read to learn about the entities and visions behind DMT art.

Changa vs. DMT: What You Need to Know
While similar (changa contains DMT), each drug has its own unique effect and feeling. Let’s compare and contrast changa vs DMT.

5-MeO-DMT Guide: Effects, Benefits, Safety, and Legality
5-Meo-DMT comes from the Sonora Desert toad. Here is everything you want to know about 5-Meo-DMT and how it compares to 4-AcO-DMT.

4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality
This guide tells you everything about 4 AcO DMT & 5 MeO DMT, that belong to the tryptamine class, and are similar but slightly different to DMT.

How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.

 

Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.

 

The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.

 

Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.

 

Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.

 

The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.

 

Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.

 

Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.

 

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.

 

Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.

 

Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.

 

Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.

 

Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?

 

Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.

 

Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.

 

Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

Related Posts

Ready to explore the frontiers of consciousness?

Sign up for the Reality Bites newsletter and embark on a journey into the world of psychedelics, mindfulness, and transformation. It’s where the curious minds gather.

Become a conscious agent with us.

Featured Partner
Cosmic Melts
Cosmic Melts are the latest mushroom gummies we’ve been munching on. Choose from five fruity flavors, each gummy containing 350mg of Amanita muscaria.
 
Amanita muscaria offers a unique (and totally legal!) mushroom experience, and Cosmic Melts is an ideal entry point for the curious consumer.
Featured Partner
EarthStar Festival
Join us for Earthstar Festival, happening October 25-27, 2024, in the magical setting of Joshua Tree, California. This three-day experience offers music, community, and transformative activities under the stars. Get ready to immerse yourself in a weekend of unforgettable moments.
 
Reality Sandwich is giving away a full VIP Camping Ticket Package for the festival. Winner announced on Monday October 7th.
Featured Partner
Organa Fuel
If you’re a human being living in the world today – you’re in the rat race. It doesn’t matter where you live, or what you do for work or play – your nervous system needs support.

Check out Organa Fuel – this liquid nutrient works at a cellular level with super potent antioxidant, antiviral, anti-inflammatory levels. All the ‘antis’ you’re after, it’s got ’em.

Our Partners

We’re now streaming consciousness and medicine music all day, every day. Turn on, tune in, drop out.

Hear from the RS community in our new video series, spotlighting shared experiences and stories with plant medicines, psychedelics, consciousness, dreams, meditation, etc.

Welcome to Reality Sandwich. Please verify that you are over 18 years of age below.

Reality Sandwich uses cookies to ensure you get the best experience on our website. By entering Reality Sandwich, you are agreeing to the Terms and Conditions and Privacy Policy.