Guide to Entheogens: Plants, Therapy, Medicine

Jump to Section

Jump to Section

The history of consciousness-expanding substances may bring to mind the counterculture of the 1960s and ’70s. However, their Indigenous use extends far beyond this historical flash in the pan. Entheogen is a neologism that highlights the ancient spiritual role of these pharmacologically diverse substances.

The human use of entheogens for spiritual and religious purposes dates back to prehistoric times. This was a period devoid of dogma and religious institutions that attempted to monopolize the sacred. For thousands of years, entheogens have played a pivotal role in shamanic societies. They have granted direct access to visceral awe and divine reverence everywhere, from the humid jungles of the Amazon to the frigid Arctic Circle. 

What Are Entheogens?

“Entheogen” is a term coined in 1979 by R. Gordon Wasson, Jonathan Ott, Carl Ruck, and other colleagues to describe psychoactive drugs, usually of plant origin, that produce transcendent experiences and facilitate spiritual development. Etymologically, the word entheogen is derived from two Greek words: Entheos (god, “theos,” within) and the root word gen (the action of becoming). Thus, entheogen means literally “becoming the divine within.”

As Carl Ruck and colleagues describe in their original 1979 article introducing the term, 

“In a strict sense, only those vision-producing drugs that can be shown to have figured in shamanic or religious rites would be designated entheogens.”

However, over the past century, entheogenic substances have found worldwide use well beyond ritualistic and shamanic settings. Moreover, organic chemistry labs have produced various synthetic substances with entheogenic effects. With this in mind, Ruck expands the definition of entheogen, noting:

“… but in a looser sense, the term could also be applied to other drugs, both natural and artificial, that induce alterations of consciousness similar to those documented for ritual ingestion of traditional entheogens.”

Roots and Other Parts

The word “entheogen” is not synonymous with other terms in the psychoactive lexicon, including psychedelic and hallucinogens. Psychedelic, which literally means “mind-manifesting,” is perhaps the most accepted term among psychonauts and researchers alike. However, the term carries the weight of contemporary Western counterculture. Thus, it arguably resonates more with the recreational, rather than the sacred and venerated, use of these substances.

In addition, entheogen rehabilitated the term “hallucinogen,” a word that, if at all, only narrowly describes the mental experience produced by the substance in question. It is also fraught with pathological associations to psychosis and similar hallucinatory states of mind.

According to many ethnobotanists and historians, entheogens have played a crucial role in the development of various world religions and spiritual traditions. Even today, many religious practitioners legally consume entheogens to produce states of ecstatic and shamanic possession, two states that are intimately intertwined.

Indeed, shamanism has been described by Mircea Eliade as the “archaic techniques of ecstasy.” The use of entheogens is just one technique in the shamanic toolkit to achieve transcendent states, often used alongside other time-honored methods such as drumming, ecstatic dance, prayer, meditation, yoga, and chanting.

Entheogenic Plants

Entheogenic plants and fungi have been venerated as sacred sacraments and tools of divination and healing among Indigenous peoples for millennia. The traditional and religious use of entheogens has thrived in many cultures: ayahuasca and yopo in the Amazon basin, mescaline-containing cacti in South and North America, psilocybin mushrooms and Salvia divinorum in southern Mexico, and iboga in western Africa. In this section, we will overview some of the most common plant-based and fungal entheogens.


Ayahuasca, also known as yage, is a Quechua word meaning “vine of the souls.” It is an entheogenic tea that Indigenous groups in the Amazon basin have used sacramentally for millennia. Most commonly, it is made from the DMT-containing shrub Psychotria viridis (known as chacruna), and the Banisteriopsis caapi vine. B. caapi acts as an MAOI, rendering the DMT in P. viridis orally active. The ritualistic use of ayahuasca is foundational to several religious organizations, including the Brazil-based União do Vegetal (UDV) church and The Santo Daime Church. 

The Indigenous people of Amazonian Peru have traditionally used ayahuasca for healing, spiritual transformation, and to attain peak mystical experiences. Historically, ayahuasqueros have claimed they received instructions on how to make ayahuasca directly from the plants or plant spirits themselves. Ayahuasca began to receive more exposure from the West following the publication of True Hallucinations by the McKenna brothers, who documented their experiences in the Amazon. 


Yopo is a powerful entheogenic snuff that has been used in healing ceremonies and rituals by a multitude of South American tribes for over 4,000 years. The name refers to the Anadenanthera peregrina tree, a perennial native to South America and the Caribbean. Its seeds, which are ground to make the snuff, contain the psychedelic tryptamines DMT, 5-MeO-DMT, and bufotenin.

Traditionally, it is consumed by having another person blow the snuff into one’s nasal cavities with a bamboo tube or similar pipe-like object. Some South American tribes have used yopo alongside the MAOI Banisteriopsis caapi, producing effects similar to those of ayahuasca.


Peyote is a small psychoactive cactus native to Mexico and the southwestern United States. The word peyote comes from the Aztec Nahuatl word peyotl. Peyote contains the psychedelic phenethylamine mescaline, which produces similar effects as LSD and psilocybin. In terms of human use, it is one of the oldest psychedelics. Archaeological evidence has shown that Native American tribes in Mesoamerica have used it for over 5,500 years. Its medicinal and spiritual use originated with the Tonkawa and Mescalero tribes. In addition, the Huichol, Chichimeca, Tarahumara, and Cora tribes have also used it sacramentally. 

By the 19th century, the ceremonial use of peyote by the Indigenous peoples of Mexico spread north to native tribes in the United States. This diffusion of peyote practices north of Mexico coincided with the establishment of the North American Church, also known as Peyotism. As of the 1979 passage of the American Indian Religious Freedom act, ceremonial use of peyote by Native Americans is legal in the United States. 

San Pedro Cacti

San Pedro is a mescaline-containing columnar cactus native to the Andes mountains in Chile, Ecuador, Peru, Bolivia, and Argentina. It is also known by the Quechua word huachuma, which translates roughly to “removing the head,” a probable nod to its ego-annihilating potential. Traditionally, San Pedro has been consumed by itself or with other plants in an entheogenic brew known as cimora. In these forms, shamanic healers use it as a spiritual tool to facilitate the divination of their patients’ afflictions and to communicate with their ancestors. 

The effects of San Pedro are characterized by out-of-body journeys, ego dissolution, and powerful empathogenic effects, all of which catalyze significant personal transformation and healing. San Pedro has been used for thousands of years by several pre-Colombian cultures, including the Cupisnique, Chavin, Lambayeque, and Moche. 

Psilocybin Mushrooms

“Psilocybin mushrooms” refers to roughly 200 gilled mushrooms that contain the serotonergic tryptamine psilocybin, and/or its derivative psilocin. The tryptamine itself is found predominantly in the genus Psilocybe, but also in other genera such as Panaeolus, Inocybe, Gymnopilus, and others. Shamanic and religious ceremonies have used psilocybin mushrooms for thousands of years. Prehistoric art across the world has depicted the mushroom, with some murals from the Sahara Desert dating as early as 9000 BCE. Shamanic cultures within pre-Colombian Mexico used psilocybin mushrooms widely. These cultures included the Olmec, Zapotec, Mixtec, Maya, and Aztec. 

The Aztecs referred to psilocybin mushrooms as teonanacatl, or “flesh of the gods.” Once the Spanish conquistadors conquered the Aztecs in the 16th century, they declared psilocybin mushroom use heresy. This forced the practice underground for several hundred years. After the ethnomycologist R. Gordon Wasson published an article in Life Magazine titled “Seeking the Magic Mushroom” in 1958, the West began to popularize magic mushrooms. This article detailed his psilocybin experience in Oaxaca, Mexico with the Mazatec mushroom shaman, Maria Sabina

Salvia Divinorum

Salvia divinorum is a psychoactive plant in the mint family, endemic to the Sierra Mazateca region of Oaxaca, Mexico. Traditionally, users consume Salvia by chewing the fresh leaves or by drinking an infusion. Salvinorin A is the main psychoactive compound found in the leaves. It produces entheogenic effects by binding to κ-opioid receptors in the brain. This atypical pharmacological action distinguishes it from the classical psychedelics, which bind mainly to the serotonin 5-HT2A receptor.

Mazatec shamans have used S. divinorum sacramentally for healing, divination, and religious communion, often when psilocybin mushrooms weren’t available. The Mazatec see the plant as an incarnation of the Virgin Mary, referring to it as “ska Maria Pastora,” meaning “the herb of Mary, the Shepherdess.”


Tabernanthe iboga, or commonly just iboga, is a rainforest shrub indigenous to central West Africa. Its roots and bark contain the tryptamine ibogaine, a pharmacologically complex alkaloid that binds to multiple neurotransmitter systems. At mid-to-high doses, ibogaine produces powerful visionary, introspective, and dissociative effects. Similar to ayahuasca, iboga has a long history of ceremonial use, particularly in the coming-of-age rituals among the practitioners of the Bwiti religion in Gabon, Africa. 

What Is Entheogen Therapy?

The tools of science are increasingly quantifying and expanding upon the time-tested Indigenous knowledge of entheogenic substances. As a result, the healing potential of these substances is becoming politically undeniable, thereby opening up new vistas for mental health treatment in the West. 

Entheogen therapy refers to the use of entheogenic substances in conjunction with therapeutic practices to heal emotional and psychological issues and catalyze significant personal and spiritual growth. The most promising molecular candidates for entheogen therapy, while certainly not the only ones, are serotonergic psychedelics such as psilocybin, LSD, and MDMA

Psilocybin, which achieved breakthrough therapy status by the FDA in 2018, has proven highly effective in treating anxiety, depression, and PTSD. Just a single dose of psilocybin can provide immediate and lasting relief from the existential fear of dying. This remarkable finding comes from the 2016 study by Roland Griffiths and colleagues.

Research on the therapeutic potential of LSD dates back to the 1950s, when extremely promising results were found in the treatment of alcoholism, anxiety, and depression. MDMA’s empathogenic effects lend itself well to the therapeutic environment, allowing patients to explore traumatic memories within a safe and connected environment without becoming emotionally overwhelmed. MDMA-assisted psychotherapy has been found to successfully address treatment-resistant PTSD in phase II clinical trials, and phase III trials are currently underway. 

What Is Entheogenic Medicine?

When treated with ritual, reverence, and respect, entheogenic medicines are powerful plant teachers that catalyze powerful energetic experiences between the ego and the transpersonal self. Such energetic experiences facilitate introspection, healing, religious expression, and unity with the source of being. 

In traditional ceremonial contexts, entheogenic medicine is taken by shamans to access the spirit world and divine the cause of their patients’ ailments. As Terence Mckenna describes in his book Food of the Gods

“The plants used by the shaman are not intended to stimulate the immune system or the body’s other natural defenses against disease. Rather, the shamanic plants allow the healer to journey into an invisible realm in which the causality of the ordinary world is replaced with the rationale of natural magic. In this realm, language, ideas, and meaning have greater power than cause and effect.”  

Shamanic diagnosing and treating, outside of the materialist models of disease, is therefore crucially dependent on regular access to the altered states of consciousness enabled by entheogenic medicine. 

Entheogenic Medicine Going Forward

In the 21st century, entheogenic medicine has emerged as an increasingly popular and more effective alternative to conventional pharmaceuticals. Iboga is becoming well-known as an anti-addictive aid to alleviating drug withdrawals and breaking out of addictive behavior patterns. It has been found to reliably reduce the rate of relapse and the intensity of drug cravings.

However, like all other entheogens, iboga doesn’t come without risks. It can be dangerous or even fatal in individuals with preexisting cardiac conditions, or when combined with certain other drugs, particularly stimulants. 

Ayahuasca ceremonies have been highly successful in treating addiction and various mental issues. However, its medicinal effects may extend beyond this efficacy as well. A 2016 paper by Frecska and colleagues investigated the medicinal effects of ayahuasca. They noted the therapeutic brew is best understood from the perspective of a “bio-psycho-social-spiritual” model.

In addition, the researchers conclude that ayahuasca “may act against chronic low-grade inflammation and oxidative stress.” specifically through its sigma-1 receptor agonist action. This receptor system is implicated in a host of diseases, including Alzheimer’s disease, Parkinson’s disease, cancer, cardiomyopathy, and more. 

It’s just a matter of time until mainstream culture more widely accepts and legalizes entheogenic medicine and therapy. Ultimately, this will allow the healing of modern-day ailments en masse with the sacred tools that Indigenous groups around the world have employed for thousands of years.

Psychedelic Resources

A Foraging Trip: Where Do Magic Mushrooms Grow?
Eager to learn more about the origin of psilocybin species? Read this article to find out where magic mushrooms grow and more!

How to Make Shroom Tea: Best Recipe and Dosage
A step by step guide on how to brew shroom tea, and why entheogenic psilocybin tea is a preferred method for psychedelic connoisseurs.

R. Gordon Wasson: Author and Mushroom Expert
Learn about R. Gordon Wasson, the “legendary mushroom expert” and popular figure within the psychonaut community.

Shrooms vs Acid: Differences and Similarities Explained
Ever wondered what the differences are between shrooms vs acid, or if you can take both together? This guide explains what you need to know.

Quantum Mechanics, Reality, and Magic Mushrooms
Scientist and author Dr. Chris Becker takes an in-depth approach in understanding how we perceive reality through magic mushrooms and quantum mechanics.

Psilocybin Guide: Effects, Common Uses, Safety
Our ultimate guide to Psilocybin has everything you want to know about this psychedelic fungi from its uses to its legal status.

The Psilocybin Experience: What’s the Deal With Magic Mushrooms?
From microdoses to macrodoses, the psilocybin experience has been sought after both medicinally and recreationally for millennia.

Psilocybin and Magic Mushroom Resources
Curious to learn more about psilocybin? This guide is a comprehensive psilocybin resource containing books, therapeutic studies, and more.

Paul Stamets Profile: Mushroom Guru, Filmmaker, Nutritionist, Scientist
Learn about Paul Stamets, read his thoughts on psilocybin mircodosing, the future of psilocybin, and his recent film “Fantastic Fungi”.

Microdosing Psilocybin & Common Dosage Explained
Microdosing, though imperceivably, is showing to have many health benefits–here is everything you want to know about microdosing psilocybin.

Psilocybin Nasal Spray: Relief for Anxiety, PTSD, and Depression
Microdosing nasal spray with psilocybin, is that possible?! Oregan a start-up Silo Wellness believes so and has created this new option for PTSD treatment.

Mazatec Mushroom Usage: Notes on Approach, Setting and Species for Curious Psilonauts
A look at traditional Mazatec psilocybin mushroom usage, and a comparison to the cliniical therapeutic approach, with an examination of the Mazatec setting and species used in veladas.

María Sabina: The Mazatec Magic Mushroom Woman
Magic mushrooms are incredibly popular today. How they became introduced to into American culture isn’t usually a topic discussed while tripping on psilocybin fungi. We all may have María Sabina to thank for exposing the Western world to the healing properties of the psilocybin mushroom.

Guide to Magic Mushroom Strains
Are there different types of psilocybin? Read our guide to learn about the different magic mushroom strains and their individual effects.

Kilindi Iyi: Mycologist, Traveler, Teacher
Learn about traveler and mycologist Kilindi Iyi known in the psychedelic community for his research and exploration of psilocybin.

How to Store Shrooms: Best Practices
How do you store shrooms for optimal shelf life? Learn how and why the proper storage method is so important.

Shroom Chocolate Recipes: How to Make Magic Mushroom Chocolates
This recipe provides step by step directions on how you can make mushroom chocolates with the necessary ingredients. Read to learn more!

Why Do People Use Psilocybin? New Johns Hopkins Study
Johns Hopkins University School of Medicines has just published a new study on psychoactive effects of psilocybin. Read here to learn more.

How-To Lemon Tek: Ultimate Guide and Recipe
This master guide will teach you how to lemon tek, preventing the onset of negative effects after consuming psilocybin. Read to learn more!

How to Intensify a Mushroom Trip
Learn about techniques like Lemon tekking, or discover the right time to consume cannabis if you are looking to intensify a mushroom trip.

How to Grow Magic Mushrooms: Step-by-Step
This step-by-step guide will show you how to grow magic mushrooms at home. Read this guide before trying it on your own.

How to Dry Magic Mushrooms: Best Practices
Read to learn more about specifics for the best practices on how to dry magic mushrooms after harvesting season.

How to Buy Psilocybin Spores
Interested in psilocybin mushrooms? We’ll walk you through all you need to know to obtain mushroom spores. Nosh on this delish How To guide.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

Having Sex on Shrooms: Good or Bad Idea?
Is having sex on shrooms a good idea or an accident waiting to happen? Find out in our guide to sex on magic mushrooms.

Gold Cap Shrooms Guide: Spores, Effects, Identification
Read this guide to learn more about the different characteristics of gold cap mushrooms, and how they differ from other psilocybin species.

Guide to Cooking with Magic Mushrooms
From cookies to smoothies and sandwiches, we cover various methods of cooking with magic mushrooms for the ultimate snack.

2020 Election: The Decriminalize Psilocybin Movement
Are you curious if mushrooms will follow in marijuana’s footsteps? Read to learn about how the U.S. is moving to decriminalize psilocybin.

Oregon’s Initiative to Legalize Mushrooms | Initiative Petition 34
Oregon continues to push ahead with their initiative to legalize Psilocybin in 2020. The measure received its official title and now needs signatures.

Canada Approves Psilocybin Treatment for Terminally-Ill Cancer Patients
Canada’s Minister of Health, Patty Hajdu approved the use of psilocybin to help ease anxiety and depression of four terminal cancer patients.

Mapping the DMT Experience
With only firsthand experiences to share, how can we fully map the DMT experience? Let’s explore what we know about this powerful psychedelic.

Guide to Machine Elves and Other DMT Entities
This guide discusses machine elves, clockwork elves, and other common DMT entities that people experience during a DMT trip.

Is the DMT Experience a Hallucination? 
What if the DMT realm was the real world, and our everyday lives were merely a game we had chosen to play?

How to Store DMT
Not sure how to store DMT? Read this piece to learn the best practices and elements of advice to keep your stuff fresh.

What Does 5-MeO-DMT Show Us About Consciousness?
How does our brain differentiate between what’s real and what’s not? Read to learn what can 5-MeO-DMT show us about consciousness.

How to Smoke DMT: Processes Explained
There are many ways to smoke DMT and we’ve outlined some of the best processes to consider before embarking on your journey.

How to Ground After DMT
Knowing what to expect from a DMT comedown can help you integrate the experience to gain as much value as possible from your journey.

How To Get DMT
What kind of plants contain DMT? Are there other ways to access this psychedelic? Read on to learn more about how to get DMT.

How DMT is Made: Everything You Need to Know
Ever wonder how to make DMT? Read our guide to learn everything you need to know about the procedures of how DMT is made.

Having Sex on DMT: What You Need to Know
Have you ever wondered about sex on DMT? Learn how the God Molecule can influence your intimate experiences.

Does the Human Brain Make DMT? 
With scientific evidence showing us DMT in the brain, what can we conclude it is there for? Read on to learn more.

How to Use DMT Vape Pens
Read to learn all about DMT vape pens including: what to know when vaping, what to expect when purchasing a DMT cartridge, and vaping safely.

DMT Resources
This article is a comprehensive DMT resource providing extensive information from studies, books, documentaries, and more. Check it out!

Differentiating DMT and Near-Death Experiences
Some say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out.

DMT Research from 1956 to the Edge of Time
From a representative sample of a suitably psychedelic crowd, you’d be hard pressed to find someone who couldn’t tell you all about Albert Hofmann’s enchanted bicycle ride after swallowing what turned out to be a massive dose of LSD. Far fewer, however, could tell you much about the world’s first DMT trip.

The Ultimate Guide to DMT Pricing
Check out our ultimate guide on DMT pricing to learn what to expect when purchasing DMT for your first time.

DMT Milking | Reality Sandwich
Indigenous cultures have used 5-MeO-DMT for centuries. With the surge in demand for psychedelic toad milk, is DMT Milking harming the frogs?

Why Does DMT Pervade Nature?
With the presence of DMT in nature everywhere – including human brains – why does it continue to baffle science?

DMT Substance Guide: Effects, Common Uses, Safety
Our ultimate guide to DMT has everything you want to know about this powerful psychedelic referred to as “the spirit molecule”.

DMT for Depression: Paving the Way for New Medicine
We’ve been waiting for an effective depression treatment. Studies show DMT for depression works even for treatment resistant patients.

Beating Addiction with DMT
Psychedelics have been studied for their help overcoming addiction. Read how DMT is helping addicts beat their substance abuse issues.

DMT Extraction: Behind the Scientific Process
Take a look at DMT extraction and the scientific process involved. Learn all you need to know including procedures and safety.

Microdosing DMT & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing DMT.

DMT Art: A Look Behind Visionary Creations
An entire genre of artwork is inspired by psychedelic trips with DMT. Read to learn about the entities and visions behind DMT art.

Changa vs. DMT: What You Need to Know
While similar (changa contains DMT), each drug has its own unique effect and feeling. Let’s compare and contrast changa vs DMT.

5-MeO-DMT Guide: Effects, Benefits, Safety, and Legality
5-Meo-DMT comes from the Sonora Desert toad. Here is everything you want to know about 5-Meo-DMT and how it compares to 4-AcO-DMT.

4-AcO-DMT Guide: Benefits, Effects, Safety, and Legality
This guide tells you everything about 4 AcO DMT & 5 MeO DMT, that belong to the tryptamine class, and are similar but slightly different to DMT.

How Much Does LSD Cost? When shopping around for that magical psychedelic substance, there can be many uncertainties when new to buying LSD. You may be wondering how much does LSD cost? In this article, we will discuss what to expect when purchasing LSD on the black market, what forms LSD is sold in, and the standard breakdown of buying LSD in quantity.   Navy Use of LSD on the Dark Web The dark web is increasingly popular for purchasing illegal substances. The US Navy has now noticed this trend with their staff. Read to learn more.   Having Sex on LSD: What You Need to Know Can you have sex on LSD? Read our guide to learn everything about sex on acid, from lowered inhibitions to LSD users quotes on sex while tripping.   A Drug That Switches off an LSD Trip A pharmaceutical company is developing an “off-switch” drug for an LSD trip, in the case that a bad trip can happen. Some would say there is no such thing.   Queen of Hearts: An Interview with Liz Elliot on Tim Leary and LSD The history of psychedelia, particularly the British experience, has been almost totally written by men. Of the women involved, especially those who were in the thick of it, little has been written either by or about them. A notable exception is Liz Elliot.   LSD Guide: Effects, Common Uses, Safety LSD, Lysergic acid diethylamide, or just acid is one of the most important psychedelics ever discovered. What did history teach us?   Microdosing LSD & Common Dosage Explained Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing LSD.   LSD Resources Curious to learn more about LSD? This guide includes comprehensive LSD resources containing books, studies and more.   LSD as a Spiritual Aid There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception. Therefore every means of improving this faculty should be used.   Legendary LSD Blotter Art: A Hidden Craftsmanship Have you ever heard of LSD blotter art? Explore the trippy world of LSD art and some of the top artists of LSD blotter art.   LSD and Exercise: Does it Work? LSD and exercise? Learn why high-performing athletes are taking hits of LSD to improve their overall potential.   Jan Bastiaans Treated Holocaust Survivors with LSD Dutch psychiatrist, Jan Bastiaans administered LSD-assisted therapy to survivors of the Holocaust. A true war hero and pioneer of psychedelic-therapy.   LSD and Spiritual Awakening I give thanks for LSD, which provided the opening that led me to India in 1971 and brought me to Neem Karoli Baba, known as Maharajji. Maharajji is described by the Indians as a “knower of hearts.”   How LSD is Made: Everything You Need to Know Ever wonder how to make LSD? Read our guide to learn everything you need to know about the procedures of how LSD is made.   How to Store LSD: Best Practices Learn the best way to store LSD, including the proper temperature and conditions to maximize how long LSD lasts when stored.   Bicycle Day: The Discovery of LSD Every year on April 19th, psychonauts join forces to celebrate Bicycle Day. Learn about the famous day when Albert Hoffman first discovered the effects of LSD.   Cary Grant: A Hollywood Legend On LSD Cary Grant was a famous actor during the 1930’s-60’s But did you know Grant experimented with LSD? Read our guide to learn more.   Albert Hofmann: LSD — My Problem Child Learn about Albert Hofmann and his discovery of LSD, along with the story of Bicycle Day and why it marks a historic milestone.   Babies are High: What Does LSD Do To Your Brain What do LSD and babies have in common? Researchers at the Imperial College in London discover that an adult’s brain on LSD looks like a baby’s brain.   1P LSD: Effects, Benefits, Safety Explained 1P LSD is an analogue of LSD and homologue of ALD-25. Here is everything you want to know about 1P LSD and how it compares to LSD.   Francis Crick, DNA & LSD Type ‘Francis Crick LSD’ into Google, and the result will be 30,000 links. Many sites claim that Crick (one of the two men responsible for discovering the structure of DNA), was either under the influence of LSD at the time of his revelation or used the drug to help with his thought processes during his research. Is this true?   What Happens If You Overdose on LSD? A recent article presented three individuals who overdosed on LSD. Though the experience was unpleasant, the outcomes were remarkably positive.

The Ayahuasca Experience
Ayahuasca is both a medicine and a visionary aid. You can employ ayahuasca for physical, mental, emotional and spiritual repair, and you can engage with the power of ayahuasca for deeper insight and realization. If you consider attainment of knowledge in the broadest perspective, you can say that at all times, ayahuasca heals.


Trippy Talk: Meet Ayahuasca with Sitaramaya Sita and PlantTeachers
Sitaramaya Sita is a spiritual herbalist, pusangera, and plant wisdom practitioner formally trained in the Shipibo ayahuasca tradition.


The Therapeutic Value of Ayahuasca
My best description of the impact of ayahuasca is that it’s a rocket boost to psychospiritual growth and unfolding, my professional specialty during my thirty-five years of private practice.


Microdosing Ayahuasca: Common Dosage Explained
What is ayahuasca made of and what is considered a microdose? Explore insights with an experienced Peruvian brewmaster and learn more about this practice.


Ayahuasca Makes Neuron Babies in Your Brain
Researchers from Beckley/Sant Pau Research Program have shared the latest findings in their study on the effects of ayahuasca on neurogenesis.


The Fatimiya Sufi Order and Ayahuasca
In this interview, the founder of the Fatimiya Sufi Order,  N. Wahid Azal, discusses the history and uses of plant medicines in Islamic and pre-Islamic mystery schools.


Consideration Ayahuasca for Treatment of Post Traumatic Stress Disorder
Research indicates that ayahuasca mimics mechanisms of currently accepted treatments for PTSD. In order to understand the implications of ayahuasca treatment, we need to understand how PTSD develops.


Brainwaves on Ayahuasca: A Waking Dream State
In a study researchers shared discoveries showing ingredients found in Ayahuasca impact the brainwaves causing a “waking dream” state.


Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a pro cannabis Peruvian Shaman.


Ayahuasca Retreat 101: Everything You Need to Know to Brave the Brew
Ayahuasca has been known to be a powerful medicinal substance for millennia. However, until recently, it was only found in the jungle. Word of its deeply healing and cleansing properties has begun to spread across the world as many modern, Western individuals are seeking spiritual, mental, emotional, and physical well-being. More ayahuasca retreat centers are emerging in the Amazon and worldwide to meet the demand.


Ayahuasca Helps with Grief
A new study published in psychopharmacology found that ayahuasca helped those suffering from the loss of a loved one up to a year after treatment.


Ayahuasca Benefits: Clinical Improvements for Six Months
Ayahuasca benefits can last six months according to studies. Read here to learn about the clinical improvements from drinking the brew.


Ayahuasca Culture: Indigenous, Western, And The Future
Ayahuasca has been use for generations in the Amazon. With the rise of retreats and the brew leaving the rainforest how is ayahuasca culture changing?


Ayahuasca Guide: Effects, Common Uses, Safety
The Amazonian brew, Ayahuasca has a long history and wide use. Read our guide to learn all about the tea from its beginnings up to modern-day interest.


Ayahuasca and the Godhead: An Interview with Wahid Azal of the Fatimiya Sufi Order
Wahid Azal, a Sufi mystic of The Fatimiya Sufi Order and an Islamic scholar, talks about entheogens, Sufism, mythology, and metaphysics.


Ayahuasca and the Feminine: Women’s Roles, Healing, Retreats, and More
Ayahuasca is lovingly called “grandmother” or “mother” by many. Just how feminine is the brew? Read to learn all about women and ayahuasca.

What Is the Standard of Care for Ketamine Treatments?
Ketamine therapy is on the rise in light of its powerful results for treatment-resistant depression. But, what is the current standard of care for ketamine? Read to find out.

What Is Dissociation and How Does Ketamine Create It?
Dissociation can take on multiple forms. So, what is dissociation like and how does ketamine create it? Read to find out.

Having Sex on Ketamine: Getting Physical on a Dissociative
Curious about what it could feel like to have sex on a dissociate? Find out all the answers in our guide to sex on ketamine.

Special K: The Party Drug
Special K refers to Ketamine when used recreationally. Learn the trends as well as safety information around this substance.

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

Ketamine vs. Esketamine: 3 Important Differences Explained
Ketamine and esketamine are used to treat depression. But what’s the difference between them? Read to learn which one is right for you: ketamine vs. esketamine.

Guide to Ketamine Treatments: Understanding the New Approach
Ketamine is becoming more popular as more people are seeing its benefits. Is ketamine a fit? Read our guide for all you need to know about ketamine treatments.

Ketamine Treatment for Eating Disorders
Ketamine is becoming a promising treatment for various mental health conditions. Read to learn how individuals can use ketamine treatment for eating disorders.

Ketamine Resources, Studies, and Trusted Information
Curious to learn more about ketamine? This guide includes comprehensive ketamine resources containing books, studies and more.

Ketamine Guide: Effects, Common Uses, Safety
Our ultimate guide to ketamine has everything you need to know about this “dissociative anesthetic” and how it is being studied for depression treatment.

Ketamine for Depression: A Mental Health Breakthrough
While antidepressants work for some, many others find no relief. Read to learn about the therapeutic uses of ketamine for depression.

Ketamine for Addiction: Treatments Offering Hope
New treatments are offering hope to individuals suffering from addiction diseases. Read to learn how ketamine for addiction is providing breakthrough results.

Microdosing Ketamine & Common Dosages Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing ketamine.

How to Ease a Ketamine Comedown
Knowing what to expect when you come down from ketamine can help integrate the experience to gain as much value as possible.

How to Store Ketamine: Best Practices
Learn the best ways how to store ketamine, including the proper temperature and conditions to maximize how long ketamine lasts when stored.

How To Buy Ketamine: Is There Legal Ketamine Online?
Learn exactly where it’s legal to buy ketamine, and if it’s possible to purchase legal ketamine on the internet.

How Long Does Ketamine Stay in Your System?
How long does ketamine stay in your system? Are there lasting effects on your body? Read to discover the answers!

How Ketamine is Made: Everything You Need to Know
Ever wonder how to make Ketamine? Read our guide to learn everything you need to know about the procedures of how Ketamine is made.

Colorado on Ketamine: First Responders Waiver Programs
Fallout continues after Elijah McClain. Despite opposing recommendations from some city council, Colorado State Health panel recommends the continued use of ketamine by medics for those demonstrating “excited delirium” or “extreme agitation”.

Types of Ketamine: Learn the Differences & Uses for Each
Learn about the different types of ketamine and what they are used for—and what type might be right for you. Read now to find out!

Kitty Flipping: When Ketamine and Molly Meet
What is it, what does it feel like, and how long does it last? Read to explore the mechanics of kitty flipping.

MDMA & Ecstasy Guide: Effects, Common Uses, Safety
Our ultimate guide to MDMA has everything you want to know about Ecstasy from how it was developed in 1912 to why it’s being studied today.

How To Get the Most out of Taking MDMA as a Couple
Taking MDMA as a couple can lead to exciting experiences. Read here to learn how to get the most of of this love drug in your relationship.

Common MDMA Dosage & Microdosing Explained
Microdosing, though imperceivable, is showing to have many health benefits–here is everything you want to know about microdosing MDMA.

Having Sex on MDMA: What You Need to Know
MDMA is known as the love drug… Read our guide to learn all about sex on MDMA and why it is beginning to makes its way into couple’s therapy.

How MDMA is Made: Common Procedures Explained
Ever wonder how to make MDMA? Read our guide to learn everything you need to know about the procedures of how MDMA is made.

Hippie Flipping: When Shrooms and Molly Meet
What is it, what does it feel like, and how long does it last? Explore the mechanics of hippie flipping and how to safely experiment.

How Cocaine is Made: Common Procedures Explained
Ever wonder how to make cocaine? Read our guide to learn everything you need to know about the procedures of how cocaine is made.

A Christmas Sweater with Santa and Cocaine
This week, Walmart came under fire for a “Let it Snow” Christmas sweater depicting Santa with lines of cocaine. Columbia is not merry about it.

Ultimate Cocaine Guide: Effects, Common Uses, Safety
This guide covers what you need to know about Cocaine, including common effects and uses, legality, safety precautions and top trends today.

NEWS: An FDA-Approved Cocaine Nasal Spray
The FDA approved a cocaine nasal spray called Numbrino, which has raised suspicions that the pharmaceutical company, Lannett Company Inc., paid off the FDA..

The Ultimate Guide to Cannabis Bioavailability
What is bioavailability and how can it affect the overall efficacy of a psychedelic substance? Read to learn more.

Cannabis Research Explains Sociability Behaviors
New research by Dr. Giovanni Marsicano shows social behavioral changes occur as a result of less energy available to the neurons. Read here to learn more.

The Cannabis Shaman
If recreational and medical use of marijuana is becoming accepted, can the spiritual use as well? Experiential journalist Rak Razam interviews Hamilton Souther, founder of the 420 Cannabis Shamanism movement…

Cannabis Guide: Effects, Common Uses, Safety
Our ultimate guide to Cannabis has everything you want to know about this popular substances that has psychedelic properties.

Cannabis and Ayahuasca: Mixing Entheogenic Plants
Cannabis and Ayahuasca: most people believe they shouldn’t be mixed. Read this personal experience peppered with thoughts from a procannabis Peruvian Shaman.

CBD-Rich Cannabis Versus Single-Molecule CBD
A ground-breaking study has documented the superior therapeutic properties of whole plant Cannabis extract as compared to synthetic cannabidiol (CBD), challenging the medical-industrial complex’s notion that “crude” botanical preparations are less effective than single-molecule compounds.

Cannabis Has Always Been a Medicine
Modern science has already confirmed the efficacy of cannabis for most uses described in the ancient medical texts, but prohibitionists still claim that medical cannabis is “just a ruse.”

Related Posts

Ready to explore the frontiers of consciousness?

Sign up for the Reality Bites newsletter and embark on a journey into the world of psychedelics, mindfulness, and transformation. It’s where the curious minds gather.

Become a conscious agent with us.

Featured Partner

Cosmic Melts

Cosmic Melts are the latest mushroom gummies we’ve been munching on. Choose from five fruity flavors, each gummy containing 350mg of Amanita muscaria.
Amanita muscaria offers a unique (and totally legal!) mushroom experience, and Cosmic Melts is an ideal entry point for the curious consumer.
Featured Partner

Organa Fuel

If you’re a human being living in the world today – you’re in the rat race. It doesn’t matter where you live, or what you do for work or play – your nervous system needs support.

Check out Organa Fuel – this liquid nutrient works at a cellular level with super potent antioxidant, antiviral, anti-inflammatory levels. All the ‘antis’ you’re after, it’s got ’em.

Our Partners

We’re now streaming consciousness and medicine music all day, every day. Turn on, tune in, drop out.

Hear from the RS community in our new video series, spotlighting shared experiences and stories with plant medicines, psychedelics, consciousness, dreams, meditation, etc.

Welcome to Reality Sandwich. Please verify that you are over 18 years of age below.

Reality Sandwich uses cookies to ensure you get the best experience on our website. By entering Reality Sandwich, you are agreeing to the Terms and Conditions and Privacy Policy.